Document Detail

Prognostic utility of serum vitronectin levels in acute myocardial infarction.
MedLine Citation:
PMID:  24823429     Owner:  NLM     Status:  Publisher    
BACKGROUND: Vitronectin (VN) functions as a regulator of platelet adhesion and aggregation, coagulation, and fibrinolysis. The aim of this study was to assess the prognostic significance of serum VN levels in patients with acute myocardial infarction (MI).
METHODS: In this study 62 patients admitted with ST-elevation myocardial infarction (STEMI), or non-ST-elevation myocardial infarction (NSTEMI) were enrolled. Serum VN levels were measured within 6 h after onset of chest pains.
RESULTS: The VN serum levels were higher in MI patients with a mean of 2.257 µg/ml (range 1.541-4.493 µg/ml) in the STEMI group, 1.785 µg/ml (range 1.372-4.113 µg/ml) in the NSTEMI group, and 1.222 µg/ml (range 1.033-1.466 µg/ml) in the controls (p = 0.012). Major adverse cardiovascular events could be predicted at 6 months using VN levels independently of other variables [odds ratio (OR) 9.87, 95 % confidence interval (CI) 2.54-47.37, p = 0.001]. There was a significant positive correlation between VN levels and the Gensini score in NSTEMI patients (r = 0.436, p = 0.013).
CONCLUSION: The VN level may be relevant as a clinical biomarker for adverse cardiovascular outcomes not only in patients with ischemic heart disease undergoing coronary interventions, as previously reported, but also in coronary artery disease patients presenting with acute MI.
S Aslan; B Ikitimur; H A Cakmak; B Karadag; E Y Tufekcioglu; H Ekmekci; H Yuksel
Related Documents :
24187769 - An atypical evolution of tako-tsubo cardiomyopathy.
19716829 - Beneficial effects of soluble epoxide hydrolase inhibitors in myocardial infarction mod...
18053159 - Native cardiac reserve predicts survival in acute post infarction heart failure in mice.
15550779 - Effects of high- and low-dose amiodarone on mortality, left ventricular remodeling, and...
3168199 - Autonomic mechanisms and sudden death. new insights from analysis of baroreceptor refle...
20223059 - Spectroscopic diagnosis of myocardial infarction and heart failure by fourier transform...
14760919 - Echocardiographic and electrocardiographic predictors for atrial fibrillation recurrenc...
1599359 - Circadian distribution of in-hospital cardiopulmonary arrests on the general medical ward.
2711969 - Life-threatening hyperkalemia in severe heart failure.
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2014-5-15
Journal Detail:
Title:  Herz     Volume:  -     ISSN:  1615-6692     ISO Abbreviation:  Herz     Publication Date:  2014 May 
Date Detail:
Created Date:  2014-5-14     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7801231     Medline TA:  Herz     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Vernacular Title:
Prognostischer Nutzen des Vitronectin-Serumspiegels bei akutem Herzinfarkt.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  New National Diabetes Footcare Audit of England and Wales.
Next Document:  The role of cognitive group therapy and happiness training on cerebral blood flow using 99mTc-ECD br...