| Prognostic usefulness of lymph node ratio in understaged gastric cancer. | |
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MedLine Citation:
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PMID: 19950830 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND/AIMS: Gastric cancer staging based on the number of positive lymph nodes is not reliable in patients undergoing limited lymphadenectomies. The aim of the present study was to determine the prognostic influence of lymph node ratio (LR)--defined as the number of metastatic nodes divided by total of obtained nodes--in patients with less than 16 analyzed lymph nodes. METHODOLOGY: Seventy-two gastric cancer patients underwent surgery with a curative intention, obtaining less than <16 nodes. The pN (TNM 5th Ed) and LR were studied in a multivariate analysis (Cox regression). LR was classified in four groups: 0, <40%, 40-79%, and >80%, according to a previous study carried out by the authors. RESULTS: Neither the number of affected lymph nodes nor LR behaved as independent prognostic factors. Nevertheless, when locally advanced tumors were studied separately, the lymph node ratio gave more precise prognostic information, resulting in the identification a group of patients with the same pN stage who presented with different prognoses. CONCLUSIONS: LR offers better prognostic information than the number of affected lymph nodes in patients with locally advanced gastric tumors undergoing limited lymphadenectomies. Further studies are needed to confirm these results and standardize the stratification of LR. |
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Authors:
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Joaquin Rodriguez Santiago; Javier Osorio; Israel Gutierrez; Noelia Perez; Emilio Mufioz; Enrique Veloso; Constancio Marco |
Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Hepato-gastroenterology Volume: 56 ISSN: 0172-6390 ISO Abbreviation: Hepatogastroenterology Publication Date: 2009 Sep-Oct |
Date Detail:
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Created Date: 2009-12-02 Completed Date: 2009-12-15 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8007849 Medline TA: Hepatogastroenterology Country: Greece |
Other Details:
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Languages: eng Pagination: 1557-61 Citation Subset: IM |
Affiliation:
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Hospital Mutua de Terrassa, Servicio de Cirugia General y digestiva, Plaça del Doctor Robert 1. 08221 Terrassa, Spain. 25533jrs@comb.es |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Female Humans Lymph Nodes / pathology* Male Middle Aged Multivariate Analysis Neoplasm Staging Prognosis Stomach Neoplasms / pathology* |
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