| Prognostic significance of weight changes in Parkinson's disease: the Park-weight phenotype. | |
MedLine Citation:
|
PMID: 25313987 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
|
SUMMARY Neurodegenerative Parkinson's disease (PD) is associated with a changing profile of weight as the disease advances. Whilst some patients gain weight, a significant proportion of patients lose weight. PD patients have a lower body weight as compared with non-PD controls. Weight loss is not a benign phenomenon. Patients with lower initial body weight and weight losers have a higher risk of developing dyskinesia. There is a relationship between body weight and levodopa dose, patients with higher levodopa dose per kilogram are at a higher risk of dyskinesia, the risk escalates above 6 mg per kilogram. Lower weight patients have risk of undernutrition and the associated disease pathology due to frailty. Weight losers are at risk of higher mortality and poor quality of life. PD patients should be assessed for body weight and the dose of levodopa be adjusted according to periodic weight changes, supplemented by other dopaminergic medications. Patients at risk of weight loss may be identified by their severe loss of olfaction since there seems to exist the olfaction-weight-dyskinesia phenotype. Measures should be taken to prevent weight loss in at-risk patients to prevent low-weight-related adverse outcomes in PD patients. These measures may protect PD patients from motor and non-motor adverse effects as the disease advances. |
Authors:
|
Jagdish C Sharma; Michael Vassallo |
Related Documents
:
|
25430457 - Allergic diseases, immunoglobulin e, and autoimmune pancreatitis: a retrospective study... 25379317 - Acute hemorrhagic myositis in inflammatory myopathy and review of the literature. 25430527 - Ct mapping of the vertebral level of right adrenal vein. 20568667 - Repeat gamma knife surgery for incompletely obliterated cerebral arteriovenous malforma... 819447 - Neurofibromatous scoliosis. natural history and results of treatment in thirty-seven ca... 17933437 - Standardized concept for the treatment of gastrointestinal dysmotility in critically il... |
Publication Detail:
|
Type: Journal Article |
Journal Detail:
|
Title: Neurodegenerative disease management Volume: 4 ISSN: 1758-2032 ISO Abbreviation: Neurodegener Dis Manag Publication Date: 2014 Aug |
Date Detail:
|
Created Date: 2014-10-15 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 101517977 Medline TA: Neurodegener Dis Manag Country: England |
Other Details:
|
Languages: eng Pagination: 309-16 Citation Subset: IM |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: The potential of alternate sources of cells for neural grafting in Parkinson's and Huntington's dise...
Next Document: Decision-making impairments in Parkinson's disease as a by-product of defective cost-benefit analysi...