Document Detail

Prognostic significance of ventricular arrhythmias post-myocardial infarction.
MedLine Citation:
PMID:  14631474     Owner:  NLM     Status:  MEDLINE    
Despite improvements in management strategies, ventricular arrhythmias remain important markers of electrical instability and contribute to the identification of patients at increased risk of sudden cardiac death post-myocardial infarction (MI). Over the past 20 years, understanding of pathophysiological mechanisms and implications of various types of ventricular arrhythmias has evolved remarkably. This systematic review details the prognostic significance of ventricular arrhythmias classified by type and time of onset post-MI. Subacute and late premature ventricular complexes are associated with increased mortality independent of left ventricular function. Although nonsustained ventricular tachycardia (VT) in the acute phase post-MI is of questionable significance, later onset heralds poorer prognosis. Sustained monomorphic VT in the acute post-MI phase is associated with infarct extension, heart failure and increased mortality. Extensive wall motion abnormalities, left ventricular dysfunction and aneurysm formation correlate with later postinfarct sustained VT. Inhospital mortality is higher when ventricular fibrillation presents in the acute phase but long term prognosis is not adversely affected.
Paul Khairy; Bernard Thibault; Mario Talajic; Marc Dubuc; Denis Roy; Peter G Guerra; Stanley Nattel
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  The Canadian journal of cardiology     Volume:  19     ISSN:  0828-282X     ISO Abbreviation:  Can J Cardiol     Publication Date:  2003 Nov 
Date Detail:
Created Date:  2003-11-21     Completed Date:  2004-01-05     Revised Date:  2008-04-09    
Medline Journal Info:
Nlm Unique ID:  8510280     Medline TA:  Can J Cardiol     Country:  Canada    
Other Details:
Languages:  eng     Pagination:  1393-404     Citation Subset:  IM    
Department of Medicine, Montreal Heart Institute, University of Montreal, Montreal, Quebec, Canada.
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MeSH Terms
Anti-Arrhythmia Agents / therapeutic use
Clinical Trials as Topic
Myocardial Infarction / complications*,  drug therapy
Predictive Value of Tests
Risk Factors
Survival Analysis
Survival Rate
Tachycardia, Ventricular / classification*,  diagnosis*,  drug therapy,  etiology
Reg. No./Substance:
0/Anti-Arrhythmia Agents

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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