| Prognostic significance of tissue polypeptide-specific antigen (TPS) in patients with advanced non-small cell lung cancer. | |
| | |
MedLine Citation:
|
PMID: 7880606 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
In this study, we evaluated the prognostic value of the tumour marker, tissue polypeptide-specific antigen (TPS), in 203 patients with non-small cell lung cancer (NSCLC), and related this to several other known prognostic factors. TPS was significantly correlated with lactate dehydrogenase (LDH), gamma-glutamyltranspeptidase and alkaline phosphatase, and the median level of TPS in patients with stage 4 disease was significantly higher as compared to stage 3A and 3B disease. In the univariate analysis, performance status, stage of disease, LDH, alkaline phosphatase, a histology of undifferentiated large cell carcinoma and TPS all had a statistically significant association with survival. Multivariate analysis showed that stage of disease, performance status, histology and TPS were the most important prognostic factors. TPS has prognostic significance for survival in patients with advanced NSCLC, independent from performance status and stage of disease. |
| | |
Authors:
|
A van der Gaast; C H Schoenmakers; T C Kok; B G Blijenberg; W C Hop; T A Splinter |
Related Documents
:
|
20802096 - A new assay for measurement of the liberated domain i of the urokinase receptor in plas... 12220216 - Cancer of the nasal cavity: survival and factors influencing prognosis. 20146896 - Improved survival in patients with end-stage cancer treated with coenzyme q(10) and oth... 20497136 - Ascites in patients with noncirrhotic nonmalignant extrahepatic portal vein thrombosis. 20879056 - Standardized combination antibiotic treatment of mycobacterium avium complex lung disease. 22176836 - Nemo expression in human hepatocellular carcinoma and its association with clinical out... |
Publication Detail:
|
Type: Journal Article |
Journal Detail:
|
Title: European journal of cancer (Oxford, England : 1990) Volume: 30A ISSN: 0959-8049 ISO Abbreviation: Eur. J. Cancer Publication Date: 1994 |
Date Detail:
|
Created Date: 1995-04-12 Completed Date: 1995-04-12 Revised Date: 2004-11-17 |
Medline Journal Info:
|
Nlm Unique ID: 9005373 Medline TA: Eur J Cancer Country: ENGLAND |
Other Details:
|
Languages: eng Pagination: 1783-6 Citation Subset: IM |
Affiliation:
|
Department of Medical Oncology, University Hospital Rotterdam-Dijkzigt, The Netherlands. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adult Aged Aged, 80 and over Alkaline Phosphatase / blood Analysis of Variance Carcinoma, Non-Small-Cell Lung / blood*, mortality, pathology Female Humans L-Lactate Dehydrogenase / blood Lung Neoplasms / blood*, mortality, pathology Male Middle Aged Neoplasm Staging Peptides / blood* Prognosis Regression Analysis Tissue Polypeptide Antigen Tumor Markers, Biological / blood* gamma-Glutamyltransferase / blood |
| Chemical | |
Reg. No./Substance:
|
0/Peptides; 0/Tissue Polypeptide Antigen; 0/Tumor Markers, Biological; EC 1.1.1.27/L-Lactate Dehydrogenase; EC 2.3.2.2/gamma-Glutamyltransferase; EC 3.1.3.1/Alkaline Phosphatase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Adult Wilms' tumour: review of 22 cases.
Next Document: In vivo cell kinetic measurements in human oesophageal cancer: what can be learned from multiple bio...