Document Detail


Prognostic significance of tissue polypeptide-specific antigen (TPS) in patients with advanced non-small cell lung cancer.
MedLine Citation:
PMID:  7880606     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
In this study, we evaluated the prognostic value of the tumour marker, tissue polypeptide-specific antigen (TPS), in 203 patients with non-small cell lung cancer (NSCLC), and related this to several other known prognostic factors. TPS was significantly correlated with lactate dehydrogenase (LDH), gamma-glutamyltranspeptidase and alkaline phosphatase, and the median level of TPS in patients with stage 4 disease was significantly higher as compared to stage 3A and 3B disease. In the univariate analysis, performance status, stage of disease, LDH, alkaline phosphatase, a histology of undifferentiated large cell carcinoma and TPS all had a statistically significant association with survival. Multivariate analysis showed that stage of disease, performance status, histology and TPS were the most important prognostic factors. TPS has prognostic significance for survival in patients with advanced NSCLC, independent from performance status and stage of disease.
Authors:
A van der Gaast; C H Schoenmakers; T C Kok; B G Blijenberg; W C Hop; T A Splinter
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  European journal of cancer (Oxford, England : 1990)     Volume:  30A     ISSN:  0959-8049     ISO Abbreviation:  Eur. J. Cancer     Publication Date:  1994  
Date Detail:
Created Date:  1995-04-12     Completed Date:  1995-04-12     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  9005373     Medline TA:  Eur J Cancer     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  1783-6     Citation Subset:  IM    
Affiliation:
Department of Medical Oncology, University Hospital Rotterdam-Dijkzigt, The Netherlands.
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MeSH Terms
Descriptor/Qualifier:
Adult
Aged
Aged, 80 and over
Alkaline Phosphatase / blood
Analysis of Variance
Carcinoma, Non-Small-Cell Lung / blood*,  mortality,  pathology
Female
Humans
L-Lactate Dehydrogenase / blood
Lung Neoplasms / blood*,  mortality,  pathology
Male
Middle Aged
Neoplasm Staging
Peptides / blood*
Prognosis
Regression Analysis
Tissue Polypeptide Antigen
Tumor Markers, Biological / blood*
gamma-Glutamyltransferase / blood
Chemical
Reg. No./Substance:
0/Peptides; 0/Tissue Polypeptide Antigen; 0/Tumor Markers, Biological; EC 1.1.1.27/L-Lactate Dehydrogenase; EC 2.3.2.2/gamma-Glutamyltransferase; EC 3.1.3.1/Alkaline Phosphatase

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