Document Detail


Prognostic significance of single chromosome abnormalities in preleukemic states.
MedLine Citation:
PMID:  2790739     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Clinical outcome was evaluated in 43 patients with a myelodysplastic syndrome or myeloproliferative disorder and a bone marrow clone containing a single chromosome abnormality: monosomy 7/del(7q), trisomy 8, i(17q), del(5q), del(20q), or a t(2;11). Those with one of the first three abnormalities (22 patients) had shorter survival, more frequent progression to leukemia, and less response to treatment with 13-Cis-retinoic acid than did those in the latter three groups (21 patients). Additional data on these subgroups of preleukemic patients may confirm the prognostic value of such karyotypic information.
Authors:
P C Nowell; E C Besa
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Cancer genetics and cytogenetics     Volume:  42     ISSN:  0165-4608     ISO Abbreviation:  Cancer Genet. Cytogenet.     Publication Date:  1989 Oct 
Date Detail:
Created Date:  1989-11-01     Completed Date:  1989-11-01     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  7909240     Medline TA:  Cancer Genet Cytogenet     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1-7     Citation Subset:  IM    
Affiliation:
Department of Pathology, University of Pennsylvania School of Medicine, Philadelphia.
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MeSH Terms
Descriptor/Qualifier:
Chromosome Aberrations*
Follow-Up Studies
Genetic Markers
Humans
Myelodysplastic Syndromes / genetics,  mortality
Myeloproliferative Disorders / genetics,  mortality
Preleukemia / genetics*,  mortality
Prognosis
Grant Support
ID/Acronym/Agency:
CA-42232/CA/NCI NIH HHS
Chemical
Reg. No./Substance:
0/Genetic Markers

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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