Document Detail

Prognostic significance of single chromosome abnormalities in preleukemic states.
MedLine Citation:
PMID:  2790739     Owner:  NLM     Status:  MEDLINE    
Clinical outcome was evaluated in 43 patients with a myelodysplastic syndrome or myeloproliferative disorder and a bone marrow clone containing a single chromosome abnormality: monosomy 7/del(7q), trisomy 8, i(17q), del(5q), del(20q), or a t(2;11). Those with one of the first three abnormalities (22 patients) had shorter survival, more frequent progression to leukemia, and less response to treatment with 13-Cis-retinoic acid than did those in the latter three groups (21 patients). Additional data on these subgroups of preleukemic patients may confirm the prognostic value of such karyotypic information.
P C Nowell; E C Besa
Related Documents :
10399109 - Changes in granulocyte-macrophage colony formation in relation to chemotherapy and clin...
6118669 - Therapeutic selectivity of and predication of response to 2'-deoxycoformycin in acute l...
7947269 - Increased expression of myeloid antigen markers in adult acute lymphoblastic leukaemia ...
1058669 - Cytogenetic studies of the spleen in chronic granulocytic leukaemia.
20421539 - Functional activity of the oct-1 protein is predictive of long-term outcome in patients...
8946929 - Tumor suppressor gene alteration in adult acute lymphoblastic leukemia (all). analysis ...
9191509 - Sudden cardiac death in the adult with congenital heart disease.
25202829 - Bacterial translocation and plasma cytokines during transcatheter and open-heart aortic...
16105129 - Association between adenomas of rectosigmoid colon and metabolic syndrome features in a...
Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Cancer genetics and cytogenetics     Volume:  42     ISSN:  0165-4608     ISO Abbreviation:  Cancer Genet. Cytogenet.     Publication Date:  1989 Oct 
Date Detail:
Created Date:  1989-11-01     Completed Date:  1989-11-01     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  7909240     Medline TA:  Cancer Genet Cytogenet     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1-7     Citation Subset:  IM    
Department of Pathology, University of Pennsylvania School of Medicine, Philadelphia.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Chromosome Aberrations*
Follow-Up Studies
Genetic Markers
Myelodysplastic Syndromes / genetics,  mortality
Myeloproliferative Disorders / genetics,  mortality
Preleukemia / genetics*,  mortality
Grant Support
Reg. No./Substance:
0/Genetic Markers

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Membrane specializations in the satellite cells of the chicken ciliary ganglion.
Next Document:  Characterization of three human malignant mesothelioma cell lines.