Document Detail

Prognostic significance of resting anterior thallium-201 defects in patients with inferior myocardial infarction.
MedLine Citation:
PMID:  7431099     Owner:  NLM     Status:  MEDLINE    
To determine whether Tl-201 scintigraphy performed at rest during the late hospital phase of inferior myocardial infarction can predict subsequent coronary events, 25 patients with historical, enzymatic, and electrocardiographic criteria of transmural inferior infarction underwent serial imaging with computer quantification 7-35 days after admission. All 25 patients had inferior defects, and 13 (52%) also had anterior defects implying stenosis of the left anterior descending coronary artery. The patients were divided into those with inferior and anterior perfusion defects (Group 1) and those with inferior defects alone (Group 2). In Group 1, three patients had persistent defects in the anterior wall and ten had initial defects with redistribution. New or recurrent coronary events--which included new onset or progression of angina pectoris, sudden death, reinfarction, and congestive heart failure--were recorded over an average 7.2 months of followup (range 3-9 mo) for all patients. Ten of 13 (77%) patients in Group 1 had 17 coronary events and four of 12 (33%) patients in Group 2 had six coronary events (p < 0.02). Nine patients in Group 1 and three in Group 2 developed angina (p < 0.03). The apparently increased prevalence in Group 1 of sudden death (8% against 0%), reinfarction (8% against 0%), and congestive heart failure (46% against 25%) was not statistically significant. Thus resting Tl-201 scintigraphy with computer quantification is a highly sensitive method to detect inferior myocardial infarction even in the late hospital phase. Moreover, it appears to identify those patients with inferior infarction at high risk for subsequent coronary events, presumably due to stenosis of the left anterior descending coronary artery.
R S Gibson; G J Taylor; D D Watson; B C Berger; R S Crampton; R P Martin; G A Beller
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of nuclear medicine : official publication, Society of Nuclear Medicine     Volume:  21     ISSN:  0161-5505     ISO Abbreviation:  J. Nucl. Med.     Publication Date:  1980 Nov 
Date Detail:
Created Date:  1981-01-26     Completed Date:  1981-01-26     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0217410     Medline TA:  J Nucl Med     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1015-21     Citation Subset:  IM    
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MeSH Terms
Coronary Disease / complications,  radionuclide imaging*
Middle Aged
Myocardial Infarction / complications,  radionuclide imaging*
Radioisotopes / diagnostic use
Thallium / diagnostic use*
Time Factors
Reg. No./Substance:
0/Radioisotopes; 7440-28-0/Thallium

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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