| Prognostic significance of preoperative imaging in recipients of living donor liver transplantation for hepatocellular carcinoma. | |
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MedLine Citation:
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PMID: 21343876 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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BACKGROUND.: Accurate preoperative imaging is an important aspect of patient evaluation before liver transplantation for hepatocellular carcinoma (HCC) because the size and number of tumors are indicators of posttransplant prognosis. This study aimed to evaluate the preoperative detectability of HCC and clarify the role of preoperative assessment on prognosis after living donor liver transplantation (LDLT). METHODS.: Eighty-one patients who underwent LDLT for HCC accompanied by liver cirrhosis were reviewed. A total of 149 nodules were pathologically diagnosed as HCCs. The pathologic findings were correlated with preoperative results from contrast-enhanced computed tomography, magnetic resonance imaging, and computed tomography with angiography. RESULTS.: The detectability of small HCCs (<1 cm) and well-differentiated HCCs was significantly reduced. Forty-six of 81 cases were preoperatively judged to meet the Milan criteria, although 16 of these failed to meet the criteria according to postoperative pathologic examination. However, recurrence-free survival in the 16 cases was similar to that in the 30 cases who met the criteria. CONCLUSIONS.: The preoperative diagnostic accuracy of radiologic imaging for small-sized, well-differentiated HCCs requires improvement. However, these undetected HCCs have little effect on prognosis after LDLT, and current imaging modalities therefore provide acceptable methods of preoperative LDLT evaluation. |
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Authors:
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Keishi Sugimachi; Ken Shirabe; Akinobu Taketomi; Yuji Soejima; Tomohiro Iguchi; Kazuki Takeishi; Takeo Toshima; Shinichi Aishima; Tsuyoshi Tajima; Yoshihiko Maehara |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Transplantation Volume: 91 ISSN: 1534-6080 ISO Abbreviation: Transplantation Publication Date: 2011 Mar |
Date Detail:
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Created Date: 2011-02-23 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0132144 Medline TA: Transplantation Country: United States |
Other Details:
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Languages: eng Pagination: 570-4 Citation Subset: IM |
Affiliation:
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1 Department of Surgery and Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan. 2 Department of Anatomic Pathology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan. 3 Department of Clinical Radiology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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