Document Detail

Prognostic significance of plasma osteopontin levels in patients undergoing percutaneous coronary intervention.
MedLine Citation:
PMID:  19023151     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Osteopontin (OPN) mRNA is highly expressed in atherosclerotic plaques and plasma OPN levels are high in patients with coronary artery disease and in those with restenosis. OPN-overexpressing transgenic mice show markedly increased neointimal formation after arterial injury. METHODS AND RESULTS: The prognostic significance of the preprocedural plasma OPN level was investigated in 130 patients undergoing percutaneous coronary intervention (PCI). Patients were followed up for restenosis and major adverse cardiovascular events (MACE). At 7+/-3 months after PCI, angiography was performed again in 91 patients, of whom 40 had restenosis. Between patients with and without restenosis, OPN (492+/-200 vs 482+/-224 ng/ml) and C-reactive protein (CRP: 0.78 vs 0.70 mg/L) levels did not differ. During a 3-year follow-up, MACE occurred in 21 patients, who had higher OPN (586+/-230 vs 438+/-195 ng/ml) and CRP (1.30 vs 0.70 mg/L) levels than those without MACE (P<0.005). Both OPN and CRP levels were independent predictors for MACE. Hazard ratios for MACE were 1.3 (95% confidence interval (CI) 1.1-1.5) for a 100 ng/ml increase in OPN and 3.6 (95%CI 1.4-9.3) for CRP >1.0 mg/L. CONCLUSIONS: In patients undergoing PCI, the preprocedural OPN and CRP levels are independent predictors for further cardiovascular events, but not for restenosis.
Ryuichi Kato; Yukihiko Momiyama; Reiko Ohmori; Nobukiyo Tanaka; Hiroaki Taniguchi; Koh Arakawa; Haruo Nakamura; Fumitaka Ohsuzu
Publication Detail:
Type:  Journal Article     Date:  2008-11-21
Journal Detail:
Title:  Circulation journal : official journal of the Japanese Circulation Society     Volume:  73     ISSN:  1346-9843     ISO Abbreviation:  Circ. J.     Publication Date:  2009 Jan 
Date Detail:
Created Date:  2008-12-26     Completed Date:  2009-04-21     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101137683     Medline TA:  Circ J     Country:  Japan    
Other Details:
Languages:  eng     Pagination:  152-7     Citation Subset:  IM    
First Department of Internal Medicine, National Defense Medical College, Tokorozawa, Japan.
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MeSH Terms
Angioplasty, Transluminal, Percutaneous Coronary*
Biological Markers / blood
C-Reactive Protein / metabolism
Cardiovascular Diseases / blood,  diagnosis*
Coronary Restenosis / blood,  diagnosis*
Coronary Stenosis / blood*,  therapy*
Follow-Up Studies
Kaplan-Meiers Estimate
Logistic Models
Middle Aged
Osteopontin / blood*
Predictive Value of Tests
Reg. No./Substance:
0/Biological Markers; 106441-73-0/Osteopontin; 9007-41-4/C-Reactive Protein

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