Document Detail

Prognostic significance of myocardial ischemia during dobutamine stress echocardiography in asymptomatic patients with diabetes mellitus and no prior history of coronary events.
MedLine Citation:
PMID:  17478139     Owner:  NLM     Status:  MEDLINE    
The prognostic significance of myocardial ischemia assessed by dobutamine stress echocardiography in asymptomatic patients with diabetes mellitus who have no previous coronary artery disease remains unclear. We assessed the value of dobutamine stress echocardiography for risk stratification in 161 asymptomatic patients with type 2 diabetes (mean 62 +/- 12 years of age; 96 men) who had no previous myocardial infarction or revascularization. End point during follow-up was hard cardiac events (cardiac death and nonfatal myocardial infarction). Ischemia was detected in 45 patients (28%). During a median follow-up of 5 years, 40 patients (25%) died (18 cardiac deaths) and 7 patients had nonfatal myocardial infarction (25 hard cardiac events). An abnormal dobutamine stress echocardiogram was associated with a higher mortality compared with a normal dobutamine stress echocardiogram (p = 0.03). In an incremental multivariate analysis model, clinical predictors of hard cardiac events were age and hypercholesterolemia. Ischemia was incremental to the clinical parameters. In conclusion, myocardial ischemia is an independent predictor of cardiac events in asymptomatic diabetic patients with no previous coronary artery disease.
Fabiola B Sozzi; Abdou Elhendy; Vittoria Rizzello; Elena Biagini; Ron T van Domburg; Arend F L Schinkel; Jeroen J Bax; Eleni Vourvouri; Gian Battista Danzi; Don Poldermans
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Publication Detail:
Type:  Journal Article     Date:  2007-03-15
Journal Detail:
Title:  The American journal of cardiology     Volume:  99     ISSN:  0002-9149     ISO Abbreviation:  Am. J. Cardiol.     Publication Date:  2007 May 
Date Detail:
Created Date:  2007-05-04     Completed Date:  2007-06-05     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0207277     Medline TA:  Am J Cardiol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1193-5     Citation Subset:  AIM; IM    
IRCCS Cardiology, Fondazione Ospedale Maggiore, Milan, Italy.
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MeSH Terms
Diabetes Mellitus, Type 2 / complications*,  ultrasonography*
Echocardiography, Stress*
Follow-Up Studies
Middle Aged
Myocardial Ischemia / diagnosis*,  epidemiology
Predictive Value of Tests
Risk Assessment
Survival Rate

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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