Document Detail


Prognostic significance of ischemia modified albumin after percutaneous coronary intervention.
MedLine Citation:
PMID:  16405938     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Ischemia modified albumin (IMA) is a new biochemical marker of ischemia. IMA levels rise in patients who develop ischemia during percutaneous coronary intervention (PCI). It is unclear whether IMA elevations correlate with PCI variables. The possible prognostic value of post-PCI IMA elevation has not yet to be studied. METHODS: We studied 60 patients (mean age 61 years; 51 male) who underwent successful elective single-vessel PCI for the management of stable angina pectoris. IMA levels were measured and compared with PCI variables and target lesion revascularization rate. The median post-PCI follow up is 46 months (CI 44.6 to 47.7). RESULTS: We found that the only variable related to post-PCI IMA levels was periprocedural dissection of target vessel (147.6 vs. 141.1 kU/l, p=0.035). No correlation between high and low balloon inflation pressure (143.6 vs. 141.6 kU/l, p=0.64), short and long inflation pressure (141.5 vs. 143.6 kU/l, p=0.17), with and without stent placement (143.7 vs. 141.3 kU/l, p=0.93) was found. IMA level more then 130 kU/l was associated with higher frequency of target lesion revascularization at nearly 4-years follow-up (p=0.026). CONCLUSION: Post-PCI IMA elevation is associated with higher target lesion revascularization.
Authors:
Jaroslav Dusek; Josef St'ásek; Milos Tichý; Josef Bis; Jaroslav Gregor; Jan Vojácek; Vladimír Masín; Pavel Polanský; Miroslav Brtko; Dusan Cernohorský
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2006-01-10
Journal Detail:
Title:  Clinica chimica acta; international journal of clinical chemistry     Volume:  367     ISSN:  0009-8981     ISO Abbreviation:  Clin. Chim. Acta     Publication Date:  2006 May 
Date Detail:
Created Date:  2006-04-17     Completed Date:  2006-06-09     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  1302422     Medline TA:  Clin Chim Acta     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  77-80     Citation Subset:  IM    
Affiliation:
First Department of Internal Medicine, University Hospital Hradec Králové, Czech Republic. dusek@fnhk.cz
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MeSH Terms
Descriptor/Qualifier:
Albumins / metabolism*
Angioplasty, Transluminal, Percutaneous Coronary*
Female
Humans
Ischemia / blood,  diagnosis*,  metabolism*,  therapy
Male
Middle Aged
Neovascularization, Pathologic / blood,  pathology
Prognosis
Chemical
Reg. No./Substance:
0/Albumins

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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