| Prognostic significance of glycoprotein pMQ1 in breast cancer. | |
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MedLine Citation:
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PMID: 16392102 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: A novel glycoprotein, pMQ1, is positively correlated with increasing histological grade in malignant astrocytomas. Cerebral metastases from breast cancer have also been found to contain pMQ1-positive cells. This study aimed to determine the role of pMQ1 in primary breast cancer. METHODS: Breast cancer specimens were analysed for pMQ1 by immunohistochemistry. The expression of pMQ1 was correlated with conventional prognostic indicators. Kaplan-Meier analyses were performed to compare clinical outcome between pMQ1-positive and pMQ1-negative tumours. RESULTS: pMQ1 was expressed in most of the breast cancer specimens. The surrounding normal tissue margins and benign breast tissues always lacked pMQ1 expression. A significant positive correlation was observed between pMQ1 expression and histological grade, the presence of lymphovascular invasion and Nottingham Prognostic Index. Cancers that were pMQ1 positive were significantly more likely to develop a local recurrence. CONCLUSION: pMQ1 appears to be a tumour-associated protein. The positive correlation of pMQ1 with histological grade, presence of lymphovascular invasion and Nottingham Prognostic Index suggests that it confers an adverse prognosis. |
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Authors:
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L J Fon; T F Lioe; K A Mulligan; P G Johnston; D McCormick; R A J Spence |
Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: The British journal of surgery Volume: 93 ISSN: 0007-1323 ISO Abbreviation: Br J Surg Publication Date: 2006 Mar |
Date Detail:
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Created Date: 2006-03-06 Completed Date: 2006-04-13 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0372553 Medline TA: Br J Surg Country: England |
Other Details:
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Languages: eng Pagination: 309-14 Citation Subset: AIM; IM |
Copyright Information:
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Copyright (c) 2005 British Journal of Surgery Society Ltd. Published by John Wiley & Sons, Ltd. |
Affiliation:
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Department of Surgery, Belfast City Hospital, Belfast, UK. l.j.fon@doctors.org.uk |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Breast / chemistry Breast Neoplasms / chemistry*, pathology Female Follow-Up Studies Glycoproteins / analysis* Humans Ki-67 Antigen / analysis Lymphatic Metastasis Middle Aged Neoplasm Proteins / analysis* Neoplasm Recurrence, Local / pathology Neoplasm Staging Prognosis Receptors, Estrogen / analysis Tumor Suppressor Protein p53 / analysis |
| Chemical | |
Reg. No./Substance:
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0/Glycoproteins; 0/Ki-67 Antigen; 0/Neoplasm Proteins; 0/Receptors, Estrogen; 0/Tumor Suppressor Protein p53; 0/pMQ1 glycoprotein, human |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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