Document Detail


Prognostic significance of exercise versus resting blood pressure in patients with chronic heart failure.
MedLine Citation:
PMID:  10703898     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: Results on the prognostic value of exercise blood pressure differ among studies; this may be related to the characteristics of the studied population. OBJECTIVE: To assess the prognostic significance of blood pressure measured during exercise in patients with chronic heart failure being considered for heart transplantation. DESIGN AND METHODS: Symptom-limited bicycle exercise testing with measurement of blood pressure and respiratory gas analysis was performed in 274 potential candidates for heart transplantation. They were then followed up for mortality and cardiovascular events. RESULTS: Results are given as the mean +/- SD. The age of the patients was 51.5+/-11.0 years, the resting blood pressure was 114+/-20/75+/-12 mmHg, the peak work load was 91+/-33 W and the peak oxygen uptake was 15.1+/-5.0 ml/min per kg. The systolic blood pressure increased to 128+/-21 mmHg at 30 W and to 133+/-23 mmHg at 50% of the peak work load. During the total follow-up time of 513 years, 55 patients died and 145 suffered at least one cardiovascular event. After controlling for age, gender and body mass index, mortality and incidence of events were inversely related to the systolic pressure at 30 W or at 50% of the peak work load, or to both (P < 0.05). The inverse associations of outcome with the systolic pressure at 50% of the peak work load persisted after additional adjustment for resting pressure and for peak oxygen uptake. CONCLUSION: The data indicate that a lower exercise systolic pressure, particularly at 50% of the peak work load, is associated with a higher mortality and a greater incidence of cardiovascular events.
Authors:
R Fagard; K Pardaens; J Vanhaecke
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of hypertension     Volume:  17     ISSN:  0263-6352     ISO Abbreviation:  J. Hypertens.     Publication Date:  1999 Dec 
Date Detail:
Created Date:  2000-03-16     Completed Date:  2000-03-16     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  8306882     Medline TA:  J Hypertens     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  1977-81     Citation Subset:  IM    
Affiliation:
Department of Molecular and Cardiovascular Research, Faculty of Medicine, University of Leuven KULeuven, Belgium. robert.fagard@uz.kuleuven.ac.be
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
Aged
Blood Pressure*
Cardiac Output, Low / mortality,  physiopathology*
Chronic Disease
Exercise*
Exercise Test
Female
Follow-Up Studies
Humans
Male
Middle Aged
Oxygen Consumption
Prognosis
Rest
Systole

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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