| Prognostic significance of elevated endothelin-1 levels in patients with colorectal cancer. | |
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MedLine Citation:
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PMID: 15077924 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Prognostic factors from clinical, laboratory and pathological data of patients with colorectal cancer are essential to identify high-risk groups to whom beneficial adjuvant therapy could be given. Endothelin-1, a growth factor, has been associated with the development and spread of solid tumours. This prospective study was performed to determine whether preoperative plasma big ET-1 levels might be useful as a prognostic indicator in patients with colorectal carcinoma. METHOD: Sixty-five consecutive patients with colorectal cancer confirmed by biopsy were included prospectively into this study over a 12-month period. Plasma samples from a peripheral vein were obtained prior to surgery. Univariate analysis of survival using age (< or > 70 years), sex, Dukes' stage (A&B versus C), tumour size (< or > 50 mm), vascular invasion and plasma big ET-1 levels was performed and significant factors were then analysed with the Cox regression model. RESULTS: Three variables, age, Dukes' tumour stage and plasma big ET-1 levels, were found to have prognostic significance (p<0.05). Factors associated with a poorer prognosis were age >70 years (p=0.02), Dukes' C tumours (p=0.04) and plasma big ET-1 levels >4.2 pg/mL (p=0.02). The Cox regression model identified the same three variables as having independent prognostic value for overall survival. CONCLUSION: Preoperative plasma big ET-1 levels may be useful in predicting overall survival in patients with colorectal cancer. Plasma big ET-1 levels may be useful in the selection of high-risk lymph node-negative patients with colorectal cancer for adjuvant therapy. |
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Authors:
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C Arun; N J M London; D M Hemingway |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: The International journal of biological markers Volume: 19 ISSN: 0393-6155 ISO Abbreviation: Int. J. Biol. Markers Publication Date: 2004 Jan-Mar |
Date Detail:
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Created Date: 2004-04-13 Completed Date: 2004-10-21 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8712411 Medline TA: Int J Biol Markers Country: Italy |
Other Details:
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Languages: eng Pagination: 32-7 Citation Subset: IM |
Affiliation:
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University Department of Surgery, Leicester Royal Infirmary, Leicester, United Kingdom. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Aged Colorectal Neoplasms / blood*, diagnosis*, pathology Endothelin-1 / blood* Enzyme-Linked Immunosorbent Assay Female Humans Male Middle Aged Neoplasm Metastasis Prognosis Proportional Hazards Models Prospective Studies Time Factors Tumor Markers, Biological / blood* |
| Chemical | |
Reg. No./Substance:
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0/Endothelin-1; 0/Tumor Markers, Biological |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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