Document Detail


Prognostic significance of disease-free interval in head and neck cutaneous squamous cell carcinoma with nodal metastases.
MedLine Citation:
PMID:  23152126     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
BACKGROUND: The purpose of this study was to determine whether the disease-free interval (DFI) between treatment of primary head and neck cutaneous squamous cell carcinoma (SCC) and the development of regional metastases is an independent prognostic factor. METHODS: A retrospective analysis of 229 patients with metastatic nodal head and neck cutaneous SCC, treated with curative intent by surgery ± adjuvant radiotherapy was conducted. RESULTS: After adjusting for the effect of nodal staging, extracapsular spread, involved margins, adjuvant radiotherapy, and immunosuppression, a short DFI (≤9 months vs >9 months) was a significant predictor of disease-related mortality (hazard ratio [HR], 3.0; 95% confidence interval [CI], 1.4-6.5; p = .004) and locoregional relapse (HR, 2.0; 95% CI, 1.1-4.0; p = .044). CONCLUSION: The DFI is a potentially powerful independent prognostic factor in patients with regional metastases secondary to head and neck cutaneous SCC. It provides information before definitive treatment that may ultimately assist clinicians in applying a risk-adapted management paradigm. © 2012 Wiley Periodicals, Inc. Head Neck, 2012.
Authors:
Ardalan Ebrahimi; Jonathan R Clark; Nazanin Ahmadi; Carsten E Palme; Gary J Morgan; Michael J Veness
Related Documents :
9175316 - Clinico-prognostic implications of increased levels of soluble cd54 in the serum of b-c...
9010576 - Purine analogs in chronic lymphocytic leukemia and waldenström's macroglobulinemia.
24183796 - Evaluation and impact of residual disease in locally advanced cervical cancer after con...
19093166 - Recent advances in the treatment of philadelphia chromosome-positive acute lymphoblasti...
23253226 - Stereotactic body radiation therapy for metastasis to the adrenal glands.
22037316 - A phase ii evaluation of lapatinib in the treatment of persistent or recurrent epitheli...
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-11-14
Journal Detail:
Title:  Head & neck     Volume:  -     ISSN:  1097-0347     ISO Abbreviation:  Head Neck     Publication Date:  2012 Nov 
Date Detail:
Created Date:  2012-11-15     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8902541     Medline TA:  Head Neck     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2012 Wiley Periodicals, Inc.
Affiliation:
Sydney Head and Neck Cancer Institute, The Sydney Cancer Centre, Royal Prince Alfred Hospital, Sydney, Australia. ardalan100@hotmail.com.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Impact of transplant nephrectomy on retransplantation: a single-center retrospective study.
Next Document:  Ornithine decarboxylase and glutamate decarboxylase 65 as prognostic markers of gallbladder maligna...