Document Detail


Prognostic significance of carcinoembryonic antigen level in pleural lavage fluid for patients with lung adenocarcinoma.
MedLine Citation:
PMID:  15975381     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: Prognostic indicators for non-small cell lung cancer patients traditionally include TNM staging, pleural lavage cytology, and serum carcinoembryonic antigen levels. This prospective study evaluates carcinoembryonic antigen levels in pleural lavage fluid as a potential determinant for patients with lung adenocarcinoma. METHODS: One hundred and fifty patients underwent thoracotomy. Pleural lavage fluid was collected, and pleural lavage cytology and lavage carcinoembryonic antigen levels were determined. The control group included 40 patients with nonmalignant disease. RESULTS: Sixteen patients (10.7%) had positive pleural lavage cytologies. These patients and those with elevated serum carcinoembryonic antigen levels generally had a poor prognosis. Thirty-seven patients (24.7%), however, showed elevated lavage carcinoembryonic antigen levels, and a significant correlation with patient survival was demonstrated. Multivariate analysis confirmed these results. We also found a correlation between positive pleural lavage cytologies and serum carcinoembryonic antigen levels and patient survival in patients with pN0 disease but not in those with pN1-2 disease. Elevated lavage carcinoembryonic antigen levels, however, correlated significantly with survival rates in patients with pN1-2 disease. CONCLUSIONS: An elevated lavage carcinoembryonic antigen level is an independent prognostic determinant for patients with lung adenocarcinoma, even with advanced disease, and may be a more useful marker of subclinical microdissemination than pleural lavage cytology.
Authors:
Masaki Tomita; Tetsuya Shimizu; Yasunori Matsuzaki; Masaki Hara; Takanori Ayabe; Toshio Onitsuka
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The Annals of thoracic surgery     Volume:  80     ISSN:  1552-6259     ISO Abbreviation:  Ann. Thorac. Surg.     Publication Date:  2005 Jul 
Date Detail:
Created Date:  2005-06-24     Completed Date:  2006-08-08     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  15030100R     Medline TA:  Ann Thorac Surg     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  276-81     Citation Subset:  AIM; IM    
Affiliation:
Department of Surgery II, Miyazaki Medical College, University of Miyazaki, Miyazaki, Japan. mtomita@post.miyazaki-med.ac.jp
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MeSH Terms
Descriptor/Qualifier:
Adenocarcinoma / surgery*
Adult
Aged
Aged, 80 and over
Body Fluids / chemistry*
Carcinoembryonic Antigen / analysis*
Female
Humans
Irrigation
Lung Neoplasms / surgery*
Male
Middle Aged
Pleura
Predictive Value of Tests
Prognosis
Prospective Studies
Chemical
Reg. No./Substance:
0/Carcinoembryonic Antigen

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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