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Prognostic significance of bone invasion for oral cavity squamous cell carcinoma considered T1/T2 by AJCC size criteria.
MedLine Citation:
PMID:  23616341     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Background: It is unclear whether bone invasion in small oral cavity squamous cell carcinomas (OCSCC) results in worse prognosis. Methods: 254 OCSCC were identified and divided into 3 cohorts: 1) ≤ 4 cm with no bone invasion, 2) ≤ 4 cm with bone invasion, 3) ≥4 cm or other factors (e.g. skin invasion, deep muscle invasion, etc.) that would qualify for AJCC T4 classification aside from bone invasion. Depth of bone invasion (none, cortical, medullary) was also recorded. Results: Cohorts 1 and 2 had similar outcomes. Cohort 3 had lower rates of RC (p = 0.04), DSS (p < 0.01), and OS (p < 0.01). On multivariate analysis, margin status and medullary bone invasion were associated with worse outcomes. Conclusions: Bone invasion does not appear to significantly influence outcomes in patients with small primaries treated with surgery/radiation. Medullary bone invasion appears to result in reduced rates of control and survival. Head Neck, 2013.
Authors:
David Fried; Brandon Mullins; Mark Weissler; Carol Shores; Adam Zanation; Trevor Hackman; William Shockley; Neil Hayes; Bhishamjit S Chera
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2013-4-25
Journal Detail:
Title:  Head & neck     Volume:  -     ISSN:  1097-0347     ISO Abbreviation:  Head Neck     Publication Date:  2013 Apr 
Date Detail:
Created Date:  2013-4-25     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8902541     Medline TA:  Head Neck     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2013 Wiley Periodicals, Inc., A Wiley Company.
Affiliation:
Department of Radiation Oncology, University of North Carolina Hospitals, Chapel Hill, NC.
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