Document Detail

Prognostic significance of blood brain barrier permeability in acute hemorrhagic stroke.
MedLine Citation:
PMID:  16230847     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Blood brain barrier (BBB) disruption is accompanied by edema in the surrounding areas of the intracerebral hemorrhage (ICH). The aim of the study was to clarify the correlation between BBB breakdown and outcome in ICH. PATIENTS: Twenty-seven patients with primary ICH were included in the study. Each patient underwent CT and DTPA-SPECT, and the National Institutes of Health (NIH) and modified Rankin score were performed as well. RESULTS: DTPA-SPECT had a significant correlation with the modified Rankin score after 3 months (p = 0.008) and 6 months (p = 0.01). The CT scan was directly correlated with the NIH score on days 1, 7 and 30 (p = 0.01, p = 0.01 and p = 0.04, respectively). No correlation was found between DTPA-SPECT and CT scan data. CONCLUSIONS: The degree of BBB breakdown, as imaged by the DTPA-SPECT technique, was directly correlated with the late functional outcome. The CT scan has an inverse correlation with the NIH score. These findings may have broad clinical implications.
Yair Lampl; Olga Shmuilovich; Judith Lockman; Menahem Sadeh; Mordechai Lorberboym
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Publication Detail:
Type:  Journal Article     Date:  2005-10-17
Journal Detail:
Title:  Cerebrovascular diseases (Basel, Switzerland)     Volume:  20     ISSN:  1015-9770     ISO Abbreviation:  Cerebrovasc. Dis.     Publication Date:  2005  
Date Detail:
Created Date:  2005-11-21     Completed Date:  2006-01-17     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  9100851     Medline TA:  Cerebrovasc Dis     Country:  Switzerland    
Other Details:
Languages:  eng     Pagination:  433-7     Citation Subset:  IM    
Copyright Information:
2005 S. Karger AG, Basel
Department of Neurology, Edith Wolfson Medical Center, Holon, Israel.
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MeSH Terms
Acute Disease
Aged, 80 and over
Blood-Brain Barrier / physiology*
Cerebral Hemorrhage / radionuclide imaging*
Contrast Media
Middle Aged
Stroke / radionuclide imaging*
Technetium Tc 99m Pentetate / diagnostic use
Tomography, Emission-Computed, Single-Photon
Tomography, X-Ray Computed
Reg. No./Substance:
0/Contrast Media; 65454-61-7/Technetium Tc 99m Pentetate

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