Document Detail

Prognostic significance of alkaline phosphatase measurements in patients with osteogenic sarcoma receiving chemotherapy.
MedLine Citation:
PMID:  287547     Owner:  NLM     Status:  MEDLINE    
During the period January 1975 to August 1977, alkaline phosphatase levels in 30 patients with osteogenic sarcoma were closely followed in an attempt to determine if these measurements had clinical value in predicting the course of patients with this disease. Of 17 patients with elevated preoperative alkaline phosphatase levels, 12 recurred. Of 13 patients with normal preoperative alkaline phosphatase levels, only 4 recurred (p less than .05). Thus, alkaline phosphatase levels that were elevated preoperatively were correlated with poor prognosis. A similar correlation between postoperative alkaline phosphatase levels and prognosis could not be made.
W P Thorpe; J J Reilly; S A Rosenberg
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Cancer     Volume:  43     ISSN:  0008-543X     ISO Abbreviation:  Cancer     Publication Date:  1979 Jun 
Date Detail:
Created Date:  1979-09-27     Completed Date:  1979-09-27     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0374236     Medline TA:  Cancer     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  2178-81     Citation Subset:  AIM; IM    
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MeSH Terms
Alkaline Phosphatase / blood*
Antineoplastic Agents / administration & dosage
Bone Neoplasms / enzymology*,  therapy
Drug Therapy, Combination
Middle Aged
Osteosarcoma / enzymology*,  therapy
Time Factors
Reg. No./Substance:
0/Antineoplastic Agents; EC Phosphatase

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