| Prognostic significance of L-type amino-acid transporter 1 expression in surgically resected pancreatic cancer. | |
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MedLine Citation:
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PMID: 22805328 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: The expression of L-type amino-acid transporter 1 (LAT1) is tumour-specific and has been shown to have essential roles in cell growth and survival. However, little is known regarding the clinical significance of LAT1 expression in pancreatic cancer. This study was conducted to determine the prognostic significance of LAT1 expression. METHODS: A total of 97 consecutive patients with surgically resected pathological stage I-IV pancreatic ductal adenocarcinoma were retrospectively reviewed. Tumour sections were stained by immunohistochemistry for LAT1, CD98, Ki-67 and vascular endothelial growth factor (VEGF), and microvessel density was determined by CD34 and p53. RESULTS: L-type amino-acid transporter 1 and CD98 were highly expressed in 52.6% (51/97) and 56.7% (55/97) of cases, respectively (P=0.568). The expression of LAT1 within pancreatic cancer cells was significantly associated with disease stage, tumour size, Ki-67, VEGF, CD34, p53 and CD98. L-type amino-acid transporter 1 expression was confirmed to be a significant prognostic factor for predicting poor outcome by multivariate analysis. CONCLUSION: L-type amino-acid transporter 1 expression is a promising pathological marker for the prediction of outcome in patients with pancreatic cancer. |
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Authors:
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K Kaira; Y Sunose; K Arakawa; T Ogawa; N Sunaga; K Shimizu; H Tominaga; N Oriuchi; H Itoh; S Nagamori; Y Kanai; A Segawa; M Furuya; M Mori; T Oyama; I Takeyoshi |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2012-07-17 |
Journal Detail:
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Title: British journal of cancer Volume: 107 ISSN: 1532-1827 ISO Abbreviation: Br. J. Cancer Publication Date: 2012 Aug |
Date Detail:
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Created Date: 2012-08-09 Completed Date: 2012-10-19 Revised Date: 2013-04-16 |
Medline Journal Info:
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Nlm Unique ID: 0370635 Medline TA: Br J Cancer Country: England |
Other Details:
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Languages: eng Pagination: 632-8 Citation Subset: IM |
Affiliation:
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Department of Medicine and Molecular Science, Gunma University Graduate School of Medicine, Showa-machi, Maebashi, Gunma 371-8511, Japan. kkaira1970@yahoo.co.jp |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Aged, 80 and over Antigens, CD98 / metabolism Carcinoma, Pancreatic Ductal / metabolism*, mortality, pathology, surgery Disease-Free Survival Female Humans Immunohistochemistry Large Neutral Amino Acid-Transporter 1 / metabolism* Male Pancreatic Neoplasms / metabolism*, mortality, pathology, surgery Prognosis Tumor Markers, Biological / metabolism |
| Chemical | |
Reg. No./Substance:
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0/Antigens, CD98; 0/Large Neutral Amino Acid-Transporter 1; 0/Tumor Markers, Biological |
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