Document Detail


Prognostic significance of HER-2/neu expression in breast cancer and its relationship to other prognostic factors.
MedLine Citation:
PMID:  1678734     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Archival surgical specimens from 1,210 female breast cancer patients treated between 1968 and 1971 and with a 19-year follow-up were reanalyzed with special reference to several parameters, such as size of the primary tumor, axillary nodal involvement, histologic grade, degree of inflammatory infiltrate (LPI) of the tumor and expression of the neu oncoprotein (p185) as detected by immunohistochemistry. In a multifactorial analysis the 4 former factors were found to be independent prognostic parameters. Over-expression of p185 was found to be related to tumor size and grade and to LPI but not to pathologic nodal status. Over-expression of p185 showed a negative impact upon survival in node-positive but not in node-negative patients. However, in the subset of node-negative patients without LPI, p185 over-expression showed the same correlation with a poor prognosis as in node-positive patients. In contrast, in node-negative and LPI-positive patients, p185 over-expression correlated with a good prognosis. Also, the prognosis of patients with positive nodes, presence of LPI and no p185 over-expression was similar to that of patients with negative nodes, absence of LPI and p185 over-expression.
Authors:
F Rilke; M I Colnaghi; N Cascinelli; S Andreola; M T Baldini; R Bufalino; G Della Porta; S Ménard; M A Pierotti; A Testori
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  International journal of cancer. Journal international du cancer     Volume:  49     ISSN:  0020-7136     ISO Abbreviation:  Int. J. Cancer     Publication Date:  1991 Aug 
Date Detail:
Created Date:  1991-09-20     Completed Date:  1991-09-20     Revised Date:  2009-11-19    
Medline Journal Info:
Nlm Unique ID:  0042124     Medline TA:  Int J Cancer     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  44-9     Citation Subset:  IM    
Affiliation:
Division of Anatomical Pathology, Istituto Nazionale per lo Studio e la Cura dei Tumori, Milan, Italy.
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MeSH Terms
Descriptor/Qualifier:
Age Factors
Breast Neoplasms / diagnosis,  metabolism*,  pathology
Female
Humans
Lymphatic Metastasis
Menopause
Prognosis
Proto-Oncogene Proteins / metabolism*
Receptor, erbB-2
Survival Analysis
Tumor Markers, Biological
Chemical
Reg. No./Substance:
0/Proto-Oncogene Proteins; 0/Tumor Markers, Biological; EC 2.7.10.1/Receptor, erbB-2

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