Document Detail


Prognostic significance of DNA aneuploidy in stage I cutaneous melanoma.
MedLine Citation:
PMID:  3355269     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The prognostic significance of DNA aneuploidy was studied restrospectively in 177 Stage I cutaneous melanomas. DNA content was determined by flow cytometry of propidium iodide-stained nuclei recovered from formalin-fixed, paraffin-embedded material. Of 162 evaluable histograms, 124 were diploid, 35 aneuploid, and 3 tetraploid. Aneuploidy strongly correlated with established predictors of unfavorable prognosis, namely, thickness p less than .005, level p less than 0.005, ulceration p less than 0.005, and presence of vertical growth phase p less than 0.02. Overall, aneuploidy was strongly correlated with recurrence (p less than 0.005) and shorter disease-free survival (p less than 0.0001). Aneuploidy was an independent predictor of recurrence for tumors less than 1.5 mm thick (p less than 0.0001) and greater than or equal to 3 mm thick (p = 0.031). For melanomas 1.5-2.9 mm thick, aneuploid tumors had a 27% higher recurrence rate than diploid tumors (63% vs. 36%). This was not statistically significant (p = 0.247). In a multivariate analysis of common predictors stratified by thickness, DNA aneuploidy was the most significant independent parameter (p less than 0.002). DNA content appears to be an important stratification parameter for Stage I cutaneous melanoma.
Authors:
S M Kheir; S D Bines; J H Vonroenn; S J Soong; M M Urist; J S Coon
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Annals of surgery     Volume:  207     ISSN:  0003-4932     ISO Abbreviation:  Ann. Surg.     Publication Date:  1988 Apr 
Date Detail:
Created Date:  1988-05-06     Completed Date:  1988-05-06     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  0372354     Medline TA:  Ann Surg     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  455-61     Citation Subset:  AIM; IM    
Affiliation:
Department of Pathology, Rush Presbyterian St. Luke's Medical Center, Chicago, IL 60612.
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MeSH Terms
Descriptor/Qualifier:
Actuarial Analysis
Aneuploidy*
DNA, Neoplasm / analysis*
Flow Cytometry
Humans
Melanoma / genetics*,  mortality
Neoplasm Recurrence, Local*
Prognosis
Skin Neoplasms / genetics*,  mortality
Statistics as Topic
Grant Support
ID/Acronym/Agency:
CA13148/CA/NCI NIH HHS
Chemical
Reg. No./Substance:
0/DNA, Neoplasm
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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