Document Detail

Prognostic significance of BRCA1 expression in gastric cancer.
MedLine Citation:
PMID:  23292835     Owner:  NLM     Status:  In-Data-Review    
The breast and ovarian cancer susceptibility gene 1 (BRCA1) is a well-known tumor suppressor gene implicated in the predisposition of early-onset breast and ovarian cancer. The aim of this study is to identify the prognostic significance of BRCA1 in patients with gastric cancer undergoing surgery and platinum-based adjuvant chemotherapy. BRCA1 protein expression profiles were evaluated by immunohistochemistry (IHC) on surgical specimens of 637 gastric cancer patients. The relationships between BRCA1 expression and existing prognostic factors, platinum-based adjuvant chemotherapy, disease-free survival, and overall survival were analyzed. There were 637 stage II/III patients, of which 219 samples (34 %) were evaluated as BRCA1 IHC positive. BRCA1 expression had statistically significant association only with tumor differentiation (p = 0.004). The patients with BRCA1-positive expression had significantly prolonged overall survival (p = 0.049). The patients received platinum-based adjuvant chemotherapy showed a better prognosis (p = 0.017). The patients with BRCA1-negative expression benefited more from platinum-based adjuvant chemotherapy (p = 0.024). Multivariate analysis demonstrated that tumor size, T category, N category, vascular or nerves invasion, and platinum-based adjuvant chemotherapy were good prognostic factors for overall survival (p < 0.05). BRCA1 expression was not significantly related to overall survival (p = 0.127). The positive correlation between BRCA1 expression and overall survival suggests that patients with BRCA1 expression have a better prognosis in gastric cancer. Patients without BRCA1 expression can benefit from platinum-based adjuvant chemotherapy. However, BRCA1 expression might not be a good prognostic factor.
Wenjiao Chen; Jian Wang; Xiao Li; Jingying Li; Li Zhou; Tianzhu Qiu; Meiling Zhang; Ping Liu
Related Documents :
17388865 - Efficacy of aprepitant in management of chemotherapy-induced nausea and vomiting.
24962105 - Low-dose maintenance gemcitabine-carboplatin chemotherapy could be an alternative to co...
21059575 - The relationship of chemotherapy-induced nausea to the frequency of pericardium 6 digit...
8874675 - Influence of acupuncture and pharmacotherapy on sensitivity of sensory systems to alcoh...
18698035 - Predicting clinical outcome through molecular profiling in stage iii melanoma.
20466745 - Clinical outcome of pretreated b-cell chronic lymphocytic leukemia following alemtuzuma...
Publication Detail:
Type:  Journal Article     Date:  2013-01-05
Journal Detail:
Title:  Medical oncology (Northwood, London, England)     Volume:  30     ISSN:  1559-131X     ISO Abbreviation:  Med. Oncol.     Publication Date:  2013 Mar 
Date Detail:
Created Date:  2013-01-07     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9435512     Medline TA:  Med Oncol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  423     Citation Subset:  IM    
Department of Medical Oncology, The First Affiliated Hospital of Nanjing Medical University, No. 300, Guangzhou Road, Gulou District, Nanjing City, 210029, China.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  MicroRNA-99a/100 promotes apoptosis by targeting mTOR in human esophageal squamous cell carcinoma.
Next Document:  Leptomeningeal metastases from genitourinary cancer: The University of Texas MD Anderson Cancer Cent...