| Prognostic significance of BP1 mRNA expression level in patients with non-small cell lung cancer. | |
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MedLine Citation:
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PMID: 18420035 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVES: To examine the association of BP1 mRNA level with tumor characteristics and clinical prognosis in non-small cell lung cancer (NSCLC) patients. DESIGN AND METHODS: Tumor specimens from 98 NSCLC patients who underwent surgical resection were quantitatively determined for BP1 mRNA expression by real-time RT-PCR. RESULTS: BP1 mRNA was expressed at significantly higher levels in tumors than in adjacent nontumorous tissues and normal lung samples. The level of BP1 transcript was significantly associated with tumor histological type and cell differentiation grade, but not related with other clinicopathological factors and p53 mutations. Patients with high BP1 mRNA expression had a poorer prognosis in terms of both disease-free survival (DFS) and overall survival (OS) rates. Additionally, BP1 mRNA expression level was an independent prognostic factor for DFS. CONCLUSIONS: BP1 may be part of a pathway contributing to NSCLC development and/or progression. BP1 mRNA level could be a novel prognostic marker for NSCLC. |
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Authors:
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Man Yu; Yanfang Wan; Qinghua Zou |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2008-04-04 |
Journal Detail:
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Title: Clinical biochemistry Volume: 41 ISSN: 1873-2933 ISO Abbreviation: Clin. Biochem. Publication Date: 2008 Jul |
Date Detail:
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Created Date: 2008-06-16 Completed Date: 2008-08-06 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0133660 Medline TA: Clin Biochem Country: United States |
Other Details:
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Languages: eng Pagination: 824-30 Citation Subset: IM |
Affiliation:
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Centre for Advanced Research in Environmental Genomics (CAREG), University of Ottawa, 20 Marie Curie, Ottawa, ON, Canada K1N 6N5. myu073@uottawa.ca |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Carcinoma, Non-Small-Cell Lung
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genetics*,
pathology,
surgery Disease Progression Female Homeodomain Proteins / genetics* Humans Lung Neoplasms / genetics*, pathology, surgery Male Middle Aged Polymerase Chain Reaction Prognosis RNA, Messenger / genetics* RNA, Neoplasm / genetics, isolation & purification Smoking / genetics Transcription Factors / genetics* Transcription, Genetic |
| Chemical | |
Reg. No./Substance:
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0/DLX4 protein, human; 0/Homeodomain Proteins; 0/RNA, Messenger; 0/RNA, Neoplasm; 0/Transcription Factors |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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