| Prognostic role of left atrial volume in elderly patients with symptomatic stable chronic heart failure: comparison with left ventricular diastolic dysfunction and B-type natriuretic peptide. | |
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MedLine Citation:
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PMID: 18001356 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Left atrial (LA) volume and B-type natriuretic peptide (BNP) represent powerful outcome predictors in patients with heart failure (HF).Aim: To assess the comparative prognostic role of LA volume (indexed to body surface area, LAVi), left ventricular diastolic dysfunction (LVDD) and BNP levels on long-term outcome in patients with symptomatic but stable chronic HF. methods: We studied consecutively 46 patients with symptomatic stable chronic HF (73 +/- 10 years, 30 men), in sinus rhythm, without significant valvular disease. Echocardiographic measurements included: LV mass, LV volumes and ejection fraction, and LAVi. LVDD was graded using a comprehensive Doppler algorithm. Blood taken before echocardiography was assayed for BNP levels. Primary end point was combined: all-cause mortality and hospitalization for worsening HF. RESULTS: During 20 +/- 14 months of follow-up 19 events occurred: 8 deaths, and 11 hospitalizations for HF. In univariate analyses LAVi, LVDD, BNP levels, LV ejection fraction, LV volumes, and LV mass were significant outcome predictors (P < 0.05). At multivariate regression LAVi was the only independent predictor of outcome (hazard ratio: 1.03 per 1 ml/m(2) increase, 95% CI: 1.01-1.06, P = 0.02). CONCLUSION: Although directly related to LVDD and to BNP levels, only LAVi emerged as an independent outcome predictor in this cohort of elderly patients with symptomatic stable chronic HF. |
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Authors:
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Bogdan A Popescu; Andreea C Popescu; Francesco Antonini-Canterin; Daniela Rubin; Piero Cappelletti; Rita Piazza; Carmen Ginghina; Doina Dimulescu; Carmen C Beladan; Gian Luigi Nicolosi |
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Publication Detail:
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Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Echocardiography (Mount Kisco, N.Y.) Volume: 24 ISSN: 0742-2822 ISO Abbreviation: Echocardiography Publication Date: 2007 Nov |
Date Detail:
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Created Date: 2007-11-16 Completed Date: 2008-01-29 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8511187 Medline TA: Echocardiography Country: United States |
Other Details:
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Languages: eng Pagination: 1035-43 Citation Subset: IM |
Affiliation:
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Prof. Dr. C. C. Iliescu Institute of Cardiovascular Diseases, Bucharest, Romania. bogdan.a.popescu@gmail.com |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Aged Cardiac Volume / physiology* Chronic Disease Diastole Echocardiography, Doppler, Pulsed / methods* Female Follow-Up Studies Heart Atria / physiopathology*, ultrasonography Heart Failure, Diastolic / blood, physiopathology*, ultrasonography Humans Male Natriuretic Peptide, Brain / blood* Prognosis Risk Factors Severity of Illness Index Stroke Volume / physiology* Ventricular Dysfunction, Left / blood, physiopathology*, ultrasonography |
| Chemical | |
Reg. No./Substance:
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114471-18-0/Natriuretic Peptide, Brain |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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