Document Detail


Prognostic relevance of RUNX1 mutations in T-cell acute lymphoblastic leukemia.
MedLine Citation:
PMID:  21828118     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The runt-related transcription factor 1, RUNX1, is crucial in the development of myeloid and lymphoid cell lineages and has been reported to be mutated in myeloid malignancies in approximately 30% of cases. In this study, the mutational status of RUNX1 was investigated in 128 acute lymphoblastic leukemia patients. We detected a mutation rate of 18.3% (13 of 71) in patients with T-cell acute lymphoblastic leukemia, 3.8% (2 of 52) in patients with B-cell acute lymphoblastic leukemia and no mutation (0 of 5) in patients with natural killer cell leukemia, respectively. In T-cell acute lymphoblastic leukemia patients, RUNX1 mutations were significantly associated with higher age (P=0.017) and lower white blood cell count (P=0.038). Moreover, an inferior outcome was observed in the subgroup of early T-cell acute lymphoblastic leukemia patients carrying RUNX1 mutations for overall survival (P=0.043). In conclusion, RUNX1 mutations are an important novel biomarker for a comprehensive characterization of T-cell acute lymphoblastic leukemia with poor prognostic impact and have implications for use also in monitoring disease.
Authors:
Vera Grossmann; Wolfgang Kern; Stefan Harbich; Tamara Alpermann; Sabine Jeromin; Susanne Schnittger; Claudia Haferlach; Torsten Haferlach; Alexander Kohlmann
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Publication Detail:
Type:  Journal Article     Date:  2011-08-09
Journal Detail:
Title:  Haematologica     Volume:  96     ISSN:  1592-8721     ISO Abbreviation:  Haematologica     Publication Date:  2011 Dec 
Date Detail:
Created Date:  2011-12-07     Completed Date:  2012-04-04     Revised Date:  2013-06-28    
Medline Journal Info:
Nlm Unique ID:  0417435     Medline TA:  Haematologica     Country:  Italy    
Other Details:
Languages:  eng     Pagination:  1874-7     Citation Subset:  IM    
Affiliation:
MLL Munich Leukemia Laboratory, Max-Lebsche-Platz 31, 81377 Munich, Germany. vera.grossmann@mll.com
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MeSH Terms
Descriptor/Qualifier:
Adult
Age Factors
Core Binding Factor Alpha 2 Subunit / genetics*
Disease-Free Survival
Female
Genetic Markers
Humans
Male
Middle Aged
Mutation*
Precursor T-Cell Lymphoblastic Leukemia-Lymphoma / genetics*,  mortality*
Survival Rate
Chemical
Reg. No./Substance:
0/Core Binding Factor Alpha 2 Subunit; 0/Genetic Markers; 0/RUNX1 protein, human
Comments/Corrections

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