| Prognostic relevance of F-18 fluorodeoxyglucose positron emission tomography and computed tomography in molar pregnancy before evacuation. | |
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MedLine Citation:
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PMID: 19691261 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: To assess prognostic significance of tumor metabolic activity of molar tissue by preevacuation F-18 fluorodeoxyglucose (FDG) positron emission tomography (PET) and computed tomography (CT) in patients clinically diagnosed with molar pregnancy. STUDY DESIGN: A total of 11 consecutive patients with clinical diagnosis of molar pregnancy before evacuation were enrolled. After evacuation of molar tissue, histopathologic findings and clinical follow-up were used as reference standards for the study. RESULTS: Six patients, 5 with complete and 1 with partial hydatidiform mole, had good outcome and normalization of beta-human chorionic gonadotropin (beta-hCG) levels within 5-7 weeks of evacuation. In the other 5 patients, serial measurements showed persistently and/or progressively elevated beta-hCG serum levels. These patients were treated with first-line single methotrexate or second-line etoposide, methotrexate, actinomycin D, cyclophosphamide, vincristine (EMA/CO) chemotherapy regimen. Standardized uptake value of molar tissue within the uterus in patients with persistently/progressively elevated beta-hCG levels was significantly higher than that in patients whose serum beta-hCG levels normalized after evacuation of molar tissue. CONCLUSION: Preliminary results suggest that F-18 FDG uptake within the uterus assessed by preevacuation PET/CT is predictive for probability of high-risk features of gestational trophoblastic disease or choriocarcinoma in patients with molar pregnancy. |
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Authors:
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Ilknur Ak; Sinan Ozalp |
Publication Detail:
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Type: Case Reports; Journal Article |
Journal Detail:
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Title: The Journal of reproductive medicine Volume: 54 ISSN: 0024-7758 ISO Abbreviation: J Reprod Med Publication Date: 2009 Jul |
Date Detail:
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Created Date: 2009-08-20 Completed Date: 2009-09-23 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0173343 Medline TA: J Reprod Med Country: United States |
Other Details:
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Languages: eng Pagination: 441-6 Citation Subset: IM |
Affiliation:
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Department of Nuclear Medicine, Eskişehir Osmangazi University Medical Faculty, Eskişehir, Turkey. ilknur_ak@yahoo.com |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Adult Antineoplastic Agents / therapeutic use Chorionic Gonadotropin, beta Subunit, Human / blood* Female Fluorodeoxyglucose F18 / diagnostic use*, pharmacokinetics Humans Hydatidiform Mole / pathology, radionuclide imaging*, therapy Middle Aged Positron-Emission Tomography / methods* Pregnancy Prognosis Uterine Neoplasms / radionuclide imaging*, therapy Uterus / metabolism, pathology, radionuclide imaging* Young Adult |
| Chemical | |
Reg. No./Substance:
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0/Antineoplastic Agents; 0/Chorionic Gonadotropin, beta Subunit, Human; 63503-12-8/Fluorodeoxyglucose F18 |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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