Document Detail


Prognostic relevance of AIB1 (NCoA3) amplification and overexpression in breast cancer.
MedLine Citation:
PMID:  23322234     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
RESULTS: AIB1 expression was detected in 60 % of the tumors. It was associated with tumor size (p = 0.003), high histological grade (p < 0.0001), poor disease-specific, and overall survival (p = 0.0018 and p = 0.003). There was a strong inverse relationship between AIB1 and ERα expression (p < 0.0001). AIB1 overexpression was associated with increased Ki67 labeling index (p < 0.0001), even if analyzed for different ER expression levels. AIB1 amplification was found in 11 % of the carcinomas. It was associated with high histological grade (p = 0.0012), lymph node involvement (p = 0.0163), and poor disease-specific survival (p = 0.0032) but not with overall survival (p = 0.1672) or ER status (p = 0.4456). If ER-positive tumors were stratified according to their AIB1 amplification status, there was a significant worse disease-specific survival in cases showing AIB1 amplification (p = 0.0017). AIB1 expression is associated with unfavorable prognosis and tumor phenotype. It seems to unfold its oncogenic potential at least in part independent from its role as an ERα co-activator. AIB1 has an impact on cell cycle regulation in ERα-positive as well as ERα-negative tumors. Furthermore, AIB1 amplification characterizes a subgroup of ERα-positive breast cancer with worse outcome. Therefore, AIB1 might be helpful to identify those ERα-positive breast cancers patients who are candidates for adjuvant chemotherapy.
Authors:
E Burandt; G Jens; F Holst; F Jänicke; V Müller; A Quaas; M Choschzick; W Wilczak; L Terracciano; R Simon; G Sauter; A Lebeau
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Publication Detail:
Type:  Journal Article     Date:  2013-01-16
Journal Detail:
Title:  Breast cancer research and treatment     Volume:  137     ISSN:  1573-7217     ISO Abbreviation:  Breast Cancer Res. Treat.     Publication Date:  2013 Feb 
Date Detail:
Created Date:  2013-01-23     Completed Date:  2013-06-27     Revised Date:  2014-07-31    
Medline Journal Info:
Nlm Unique ID:  8111104     Medline TA:  Breast Cancer Res Treat     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  745-53     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Adult
Aged
Aged, 80 and over
Breast Neoplasms / genetics,  metabolism*,  mortality,  pathology
Female
Gene Amplification
Gene Dosage
Gene Expression
Humans
Ki-67 Antigen / metabolism
Middle Aged
Nuclear Receptor Coactivator 3 / genetics,  metabolism*
Prognosis
Chemical
Reg. No./Substance:
0/Ki-67 Antigen; EC 2.3.1.48/NCOA3 protein, human; EC 2.3.1.48/Nuclear Receptor Coactivator 3

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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