Document Detail


Prognostic and predictive value of thymidylate synthase expression in primary colorectal cancer.
MedLine Citation:
PMID:  20332484     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
AIM: To investigate thymidylate synthase (TS) expression in primary colorectal cancer (CRC) as a prognostic and predictive marker of benefit for adjuvant chemotherapy.
PATIENTS AND METHODS: TS expression was immuno0-histochemically (IHC) assessed on tumors from 1,389 patients with stage II and III CRC randomly assigned to either surgery alone or surgery plus 5-fluorouracil (5-FU)-based adjuvant chemotherapy.
RESULTS: In the subgroup treated with surgery alone (n=708), TS expression was prognostic using the classification of TS 0-1 versus 2-3 (p=0.045) as well as TS classified as 0-2 versus 3 (p=0.002). A high TS expression was associated with a shorter overall survival. Among patients with TS grade 3 (n=460), the subgroup treated with adjuvant chemotherapy had a significant longer OS (p=0.005).
CONCLUSION: In this study TS, immunohistochemically assessed, is a prognostic factor in CRC patients treated with surgery alone. Patients with the highest level of TS expression (grade 3) had an improved clinical outcome following adjuvant 5-FU-based chemotherapy.
Authors:
M Karlberg; K Ohrling; D Edler; M Hallström; H Ullén; P Ragnhammar
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Publication Detail:
Type:  Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Anticancer research     Volume:  30     ISSN:  1791-7530     ISO Abbreviation:  Anticancer Res.     Publication Date:  2010 Feb 
Date Detail:
Created Date:  2010-03-24     Completed Date:  2010-05-04     Revised Date:  2014-07-30    
Medline Journal Info:
Nlm Unique ID:  8102988     Medline TA:  Anticancer Res     Country:  Greece    
Other Details:
Languages:  eng     Pagination:  645-51     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Adult
Aged
Colorectal Neoplasms / enzymology*,  pathology,  therapy
Female
Humans
Immunoenzyme Techniques
Male
Middle Aged
Neoplasm Staging
Prognosis
Retrospective Studies
Survival Rate
Thymidylate Synthase / metabolism*
Chemical
Reg. No./Substance:
EC 2.1.1.45/Thymidylate Synthase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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