| Prognostic power of proadrenomedullin in community-acquired peumonia is independent on etiology. | |
| | |
MedLine Citation:
|
PMID: 22075489 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
|
Biomarkers are useful in community-acquired pneumonia (CAP). Recently, mid-regional pro-adrenomedullin (MR-proADM) has shown potential prognostic utility. We sought to determine whether this prognostic role depends on different causes of CAP.We conducted a prospective cohort study of immunocompetent patients with CAP. PSI and CURB65 severity scores, blood C-reactive protein (CRP), procalcitonin (PCT), MR-proADM, and microbiological studies were systematically performed. Patients were grouped as bacterial, viral/atypical and mixed CAP, and were followed up at 30, 90 and 180 days, and 1 year.We recruited 228 CAP patients. Identification of at least one pathogen was achieved in 155 (68%).MR-proADM levels closely correlated with increasing severity scores and showed an important predictive power for complications and short and long-term mortality (1 yr). Its addition to PSI and CURB65 significantly improved their prognostic accuracy. A cutoff of MR-proADM of 0.646 nmol·L(-1) identified as high-risk to 92% of patients scored as PSI 4 and 5 classes. MR-proADM outcome prediction power was not affected by different etiologies.MR-pro-ADM has high short and long-term prognostic accuracy, and increases that of clinical scores. The prognostic value of MR-proADM is not modified by different possible CAP etiologies. |
| | |
Authors:
|
S Bello; A B Lasierra; E Mincholé; S Fandos; M A Ruiz; E Vera; M Ferrer; R Menendez; A Torres |
Related Documents
:
|
21586939 - Double inversion recovery magnetic resonance imaging (mri) in the preoperative evaluati... 22117249 - Evaluation of the length and angulation of the styloid process in the patient with pre-... 11686439 - Rigid registration of 3-d ultrasound with mr images: a new approach combining intensity... 15458139 - Visualization of conserved structures by fusing highly variable datasets. 21755329 - Mri and thallium-201 spect in the prediction of survival in glioma. 12894979 - Neuronavigation accuracy dependence on ct and mr imaging parameters: a phantom-based st... 15455319 - Intraoperative ultrasonography in patients who undergo liver resection or transplantati... 1868649 - Inaccuracies in quantitative radionuclide renal imaging due to patient position or dive... 11906659 - Functional mri as a tool to assess vision in dogs: the optimal anesthetic. |
Publication Detail:
|
Type: JOURNAL ARTICLE Date: 2011-11-10 |
Journal Detail:
|
Title: The European respiratory journal : official journal of the European Society for Clinical Respiratory Physiology Volume: - ISSN: 1399-3003 ISO Abbreviation: - Publication Date: 2011 Nov |
Date Detail:
|
Created Date: 2011-11-14 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 8803460 Medline TA: Eur Respir J Country: - |
Other Details:
|
Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
|
*Servicio de Neumología. Hospital Universitario Miguel Servet. Zaragoza (Spain). |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Telemedicine enhances quality of forced spirometry in primary care.
Next Document: Chemoradiotherapy Alone as the Standard Treatment of Epidermoid Esophageal Carcinoma.