Document Detail


Prognostic parameters in myelodysplastic syndromes: a multiple regression analysis.
MedLine Citation:
PMID:  3345829     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The influence on survival of 21 basic clinical and hematologic parameters was evaluated in 72 patients with previously untreated myelodysplastic syndromes (MDS). Only five parameters were significant by both survival curves and multiple regression analyses: hemoglobin level, bone marrow (BM) cellularity (estimated from trephine BM biopsies), BM blast percentage, age and BM erythro/myeloid (E/M) ratio. Using these parameters, multiple regression analysis enabled us to predict 34% of the survival of all MDS patients (p less than 0.002), 38% of that of patients who had stable disease (p less than 0.04) and over 80% of that of patients who developed acute leukemia (p less than 0.02). High BM cellularity was the most predictive factor for the development of leukemia. No factor was predictive for patients who died of cytopenic or other complications.
Authors:
A Riccardi; M Giordano; P Giordano; E Cassano; M Girino; M Cazzola; P Scivetti; M Danova; G Ucci
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  European journal of haematology     Volume:  40     ISSN:  0902-4441     ISO Abbreviation:  Eur. J. Haematol.     Publication Date:  1988 Feb 
Date Detail:
Created Date:  1988-04-15     Completed Date:  1988-04-15     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8703985     Medline TA:  Eur J Haematol     Country:  DENMARK    
Other Details:
Languages:  eng     Pagination:  158-62     Citation Subset:  IM    
Affiliation:
Istituto di Clinica Medica II, Dipartimento di Medicina Interna e Terapia Medica, Matteo, Pavia, Italy.
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MeSH Terms
Descriptor/Qualifier:
Humans
Myelodysplastic Syndromes / blood,  mortality,  physiopathology*
Prognosis
Regression Analysis
Time Factors

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