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Prognostic influence of BCL2 expression in breast cancer.
MedLine Citation:
PMID:  22418857     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Although BCL2 has occasionally been suggested as a candidate prognostic factor for breast cancer, it is still not accepted as a prognostic factor. We attempted to validate the role of BCL2 as a prognostic factor of breast cancer. Data on 7,230 primary breast cancer patients from the Seoul National University Hospital Breast Care Center were analyzed. Three current prognostic models, including the St. Gallen model, the Nottingham Prognostic Index (NPI) model, and the TNM model were used for analysis of the prognostic influence of BCL2. The positive BCL2 group showed more favorable features with regard to clinicopathologic parameters than the BCL2 negative group and a strong correlation was observed between BCL2 and the hormonal receptor. The positive BCL2 group showed better prognosis in overall survival and disease free survival (log-rank test, both P < 0.001), even in all subgroups, than the BCL2 negative group. BCL2 was a significant prognostic factor in both univariate (hazard ratio [HR], 0.361; 95% CI, 0.306 to 0.426; P < .001) and multivariate analyses (HR, 0.417; 95% CI, 0.417 to 0.705; P < .001). BCL2 had a strong influence on the established prognostic models, including the St. Gallen model, the NPI model, and the TNM model. BCL2 was a powerful independent prognostic factor for breast cancer and had a strong influence on the current prognostic models. Favorable clinicopathologic features and a strong correlation with the hormonal receptor are suggested as the causes of superior survival in patients with BCL2 positive breast cancer. © 2012 Wiley-Liss, Inc.
Authors:
Ki-Tae Hwang; Jung Woo Woo; Hee Chul Shin; Han Suk Kim; Soo Kyung Ahn; Hyeong-Gon Moon; Wonshik Han; In Ae Park; Dong-Young Noh
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-3-15
Journal Detail:
Title:  International journal of cancer. Journal international du cancer     Volume:  -     ISSN:  1097-0215     ISO Abbreviation:  -     Publication Date:  2012 Mar 
Date Detail:
Created Date:  2012-3-15     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0042124     Medline TA:  Int J Cancer     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2012 Wiley-Liss, Inc.
Affiliation:
Department of Surgery, Seoul National University Boramae Medical Center, Seoul, Republic of Korea. kiterius@snu.ac.kr.
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