| Prognostic indicators of the outcome of meningococcal disease: a study of 562 patients. | |
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MedLine Citation:
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PMID: 8667405 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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To assess prognostic indicators of a fatal outcome in patients with meningococcal disease, data from 562 patients with culture-proven meningococcal disease, reported in the Netherlands between 1 April 1989 and 30 April 1990, were collected prospectively by means of a questionnaire completed by the specialist in attendance. Analysis was done by the chi2 test and multiple logistic regression. During the study period 43 patients (7.7%) died. The risk of a fatal outcome was increased in patients aged 0-5 months, 10-19 years, and > or = 50 years, in female patients and in patients presenting with coma, temperature < or = 38.0 degrees C, mean arterial pressure < or = 70 mmHg, white blood cell count < or = 10 x 10(9)/L and platelet count < or = 100 x 10(9)/L. Predisposing factors and duration of disease before admission were significantly associated with outcome, but these associations disappeared in the multivariate analysis. Race, the administration of antibiotics prior to admission, seizures and haemorrhagic skin lesions were not associated with outcome. In conclusion age, gender, coma, temperature, mean arterial pressure, white blood cell count and platelet count were independent prognostic indicators of the outcome of meningococcal disease. The assessment of these characteristics may be helpful for the identification of high risk patients, whose prognosis might be improved by prompt transfer to an intensive care unit. |
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Authors:
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M C Lodder; R L Schildkamp; H A Bijlmer; J Dankert; D J Kuik; R J Scholten |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Journal of medical microbiology Volume: 45 ISSN: 0022-2615 ISO Abbreviation: J. Med. Microbiol. Publication Date: 1996 Jul |
Date Detail:
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Created Date: 1996-08-06 Completed Date: 1996-08-06 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0224131 Medline TA: J Med Microbiol Country: SCOTLAND |
Other Details:
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Languages: eng Pagination: 16-20 Citation Subset: IM |
Affiliation:
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Institute for Research in Extramural Medicine, Vrije Universiteit, Amsterdam, The Netherlands. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Adult Blood Pressure Body Temperature Causality Child Child, Preschool Female Follow-Up Studies Humans Infant Infant, Newborn Leukocyte Count Logistic Models Male Meningococcal Infections / mortality* Middle Aged Multivariate Analysis Netherlands / epidemiology Odds Ratio Platelet Count Prognosis Prospective Studies Questionnaires |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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