Document Detail

Prognostic importance of pulmonary hypertension in patients with heart failure.
MedLine Citation:
PMID:  17437745     Owner:  NLM     Status:  MEDLINE    
Pulmonary hypertension is a well-known complication in heart failure, but its prognostic importance is less well established. This study assessed the risk associated with pulmonary hypertension in patients with heart failure with preserved or reduced left ventricular (LV) ejection fractions. Patients with known or presumed heart failure (n = 388) underwent the echocardiographic assessment of pulmonary systolic pressure and LV ejection fraction. Patients were followed for up to 5.5 years. Increased pulmonary pressure was associated with increased short- and long-term mortality (p <0.0001 and p = 0.003, respectively). This relation was also present when stratifying patients by reduced or preserved LV function. A Cox proportional-hazards model apportioned a 9% increase in mortality per 5 mm Hg increase in right ventricular systolic pressure (p = 0.0008), independent of age and known chronic obstructive lung disease, heart failure, and impaired renal function. In conclusion, pulmonary hypertension is associated with increased short- and long-term mortality in patients with reduced LV ejection fractions and also in patients with preserved LV ejection fractions.
Jesper Kjaergaard; Dilek Akkan; Kasper Karmark Iversen; Erik Kjoller; Lars Køber; Christian Torp-Pedersen; Christian Hassager
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Publication Detail:
Type:  Comparative Study; Journal Article; Multicenter Study; Randomized Controlled Trial; Research Support, Non-U.S. Gov't     Date:  2007-03-08
Journal Detail:
Title:  The American journal of cardiology     Volume:  99     ISSN:  0002-9149     ISO Abbreviation:  Am. J. Cardiol.     Publication Date:  2007 Apr 
Date Detail:
Created Date:  2007-04-17     Completed Date:  2007-06-05     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0207277     Medline TA:  Am J Cardiol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1146-50     Citation Subset:  AIM; IM    
The Heart Centre, Rigshospitalet, Copenhagen, Demark.
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MeSH Terms
Age Factors
Aged, 80 and over
Cardiac Output, Low / physiopathology*
Diabetes Complications / physiopathology
Echocardiography, Doppler
Follow-Up Studies
Hypertension, Pulmonary / physiopathology*
Kidney Diseases / physiopathology
Prospective Studies
Pulmonary Disease, Chronic Obstructive / physiopathology
Pulmonary Wedge Pressure / physiology
Risk Assessment
Smoking / physiopathology
Stroke Volume / physiology
Survival Rate
Ventricular Pressure / physiology

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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