Document Detail

Prognostic importance of chronic kidney disease in Japanese patients with chronic heart failure.
MedLine Citation:
PMID:  18219149     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Renal insufficiency is common in patients with chronic heart failure (CHF), so to improve the prognosis of patients with cardiovascular risks clinical guidelines recommend estimating the glomerular filtration rate (GFR), which detects chronic kidney disease more accurately than does the serum creatinine level alone. However, the clinical usefulness of the estimated GFR (eGFR) in Japanese CHF patients is still unclear. METHODS AND RESULTS: Of 1,278 patients registered in a Japanese CHF registry, termed the Chronic Heart Failure Analysis and Registry in the Tohoku District study, the study population included 920 symptomatic patients with sufficient data. Baseline eGFR (ml .min(-1) . 1.73 m(-2)) was calculated using the Cockcroft-Gault equation. Patients were divided into three groups based on eGFR: > or =60, 30-59, and <30 ml . min(-1) .1.73 m(-2). Kaplan-Meier analysis revealed that the incidence of the combined event of all-cause death and admission because of CHF was significantly higher in patients with reduced eGFR and such patients were older and more frequently had an ischemic etiology of CHF, a higher prevalence of diabetes, lower hemoglobin level, and higher B-type natriuretic peptide level. Multivariate Cox regression analysis showed that reduced eGFR was significantly associated with the combined endpoint. CONCLUSIONS: GFR should be evaluated in all Japanese patients with CHF to improve risk stratification and treatment.
Nobuyuki Shiba; Mika Matsuki; Jun Takahashi; Tomohiro Tada; Jun Watanabe; Hiroaki Shimokawa
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Publication Detail:
Type:  Clinical Trial; Journal Article; Multicenter Study    
Journal Detail:
Title:  Circulation journal : official journal of the Japanese Circulation Society     Volume:  72     ISSN:  1346-9843     ISO Abbreviation:  Circ. J.     Publication Date:  2008 Feb 
Date Detail:
Created Date:  2008-01-25     Completed Date:  2008-05-21     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101137683     Medline TA:  Circ J     Country:  Japan    
Other Details:
Languages:  eng     Pagination:  173-8     Citation Subset:  IM    
Department of CardiovascularMedicine, Tohoku University Graduate School of Medicine, 1-1Seiryo-machi, Aoba-ku, Sendai 980-8574, Japan. <>
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MeSH Terms
Aged, 80 and over
Asian Continental Ancestry Group
Chronic Disease
Creatinine / blood
Glomerular Filtration Rate*
Heart Failure / blood,  complications,  mortality,  physiopathology*
Middle Aged
Practice Guidelines as Topic
Predictive Value of Tests
Renal Insufficiency / blood,  etiology,  mortality,  physiopathology*
Risk Assessment
Survival Rate
Reg. No./Substance:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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