Document Detail

Prognostic importance of DNA flow cytometry in non-Hodgkin's lymphomas.
MedLine Citation:
PMID:  3722408     Owner:  NLM     Status:  MEDLINE    
Eighty one cases of non-Hodgkin's lymphoma were examined by DNA flow cytometry, using fixed embedded histological tissue. The frequency of detection of DNA aneuploidy and the values for S phase fractions depended on the histological subtype and grade of lymphoma. Twenty two of the patients with low grade centroblastic/centrocytic non-Hodgkin's lymphoma had repeat biopsies. Eleven of these patients remained histologically and cytometrically stable, but the remaining eleven transformed into high grade non-Hodgkin's lymphoma. The mean value for the S phase fraction in the initial biopsy specimens from patients which transformed was higher than that for patients whose lymphomas remained stable (p less than 0.001). It is proposed that estimates of S phase fraction prospectively identify patients with low grade non-Hodgkin's lymphoma at risk from transformation.
J C Macartney; R S Camplejohn; J Alder; M G Stone; G Powell
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of clinical pathology     Volume:  39     ISSN:  0021-9746     ISO Abbreviation:  J. Clin. Pathol.     Publication Date:  1986 May 
Date Detail:
Created Date:  1986-07-30     Completed Date:  1986-07-30     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  0376601     Medline TA:  J Clin Pathol     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  542-6     Citation Subset:  AIM; IM    
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MeSH Terms
Cell Transformation, Neoplastic
DNA, Neoplasm / analysis*
Flow Cytometry
Lymph Nodes / pathology
Lymphoma / analysis*,  pathology
Reg. No./Substance:
0/DNA, Neoplasm

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