Document Detail

Prognostic implications of periodic epileptiform discharges.
MedLine Citation:
PMID:  19667220     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Periodic epileptiform discharges (PEDs) are an abnormal finding on electroencephalograms (EEGs), the significance of which is uncertain. OBJECTIVE: To investigate long-term outcome in patients with PEDs. DESIGN: We retrospectively analyzed the outcomes of patients who had PEDs diagnosed during a 7-year period. We abstracted and tabulated clinical parameters from the time of EEG, imaging findings, EEG measurements, and subsequent clinical outcome from medical records. We used descriptive, inferential, and logistic regression analysis to determine the factors associated with clinical outcomes in patients with PEDs. We divided PEDs into the following subgroups: periodic lateralized epileptiform discharges (PLEDs), generalized PEDs, and bilateral PEDs and analyzed these subgroups individually. SETTING: University-affiliated teaching hospital. Subjects One hundred sixty-two patients with PEDs. RESULTS: We obtained complete clinical, neuroimaging, neurophysiologic, and long-term outcome data in 118 patients. In the subgroup of patients with PLEDs, absence of seizures at onset (odds ratio, 0.21 per point; 95% confidence interval, 0.04-0.97) and an acute etiology for the PLEDs (odds ratio, 0.14 per point; 95% confidence interval, 0.03-0.72) were associated with death. A nonneoplastic cause for PLEDs was associated with independent functionality (odds ratio, 0.45 per point; 95% confidence interval, 0.3-0.67). CONCLUSION: In patients with PLEDs, the absence of clinical seizures at the time of detection and presumed acute etiology are associated with death, whereas a nonneoplastic etiology was associated with a good clinical outcome.
Daniel San Juan Orta; Keith H Chiappa; Alejandro Z Quiroz; Daniel J Costello; Andrew J Cole
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Archives of neurology     Volume:  66     ISSN:  1538-3687     ISO Abbreviation:  Arch. Neurol.     Publication Date:  2009 Aug 
Date Detail:
Created Date:  2009-08-11     Completed Date:  2009-08-20     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0372436     Medline TA:  Arch Neurol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  985-91     Citation Subset:  AIM; IM    
Epilepsy Service, Massachusetts General Hospital, 55 Fruit St, Boston, MA 02114, USA.
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MeSH Terms
Aged, 80 and over
Brain / pathology,  physiopathology
Brain Diseases / diagnosis,  mortality
Brain Injuries / diagnosis,  mortality
Brain Neoplasms / diagnosis,  mortality
Disability Evaluation
Dominance, Cerebral / physiology
Epilepsies, Partial / diagnosis,  etiology,  mortality
Epilepsy / diagnosis*,  etiology,  mortality
Epilepsy, Generalized / diagnosis,  etiology,  mortality
Follow-Up Studies
Magnetic Resonance Imaging
Middle Aged
Odds Ratio
Retrospective Studies
Signal Processing, Computer-Assisted*
Tomography, X-Ray Computed
Young Adult

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