Document Detail


Prognostic implications of the immunophenotype in biphenotypic acute leukemia.
MedLine Citation:
PMID:  18398737     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The present study retrospectively analyzed clinicopathological and clinical data from 43 adult patients with biphenotypic acute leukemia (BAL) from 11 Korean institutes. The incidence of BAL was 2.1% among acute leukemias. In terms of immunophenotype, 31 patients had myeloid plus B-lymphoid (M + B), 10 had myeloid plus T-lymphoid (M + T), one had myeloid plus B-lymphoid plus T-lymphoid (M + B + T), and one had B-lymphoid plus T-lymphoid (B + T). Patients with M + T phenotype had significantly lower CR rate (55.6% vs. 88.0%, P = 0.039) and lower overall survival (0% vs. 33.9% at 5 years, P = 0.028) than those with M + B phenotype. Our results suggest that immunophenotype has prognostic implications in adult patients with BAL.
Authors:
Je-Hwan Lee; Yoo Hong Min; Chul Won Chung; Byoung Kook Kim; Hwi-Joong Yoon; Deog-Yeon Jo; Ho-Jin Shin; Soo-Mee Bang; Jong-Ho Won; Dae Young Zang; Hyeoung Joon Kim; Hyun-Sook Chi; Kyoo-Hyung Lee; June-Won Cheong; Jin Seok Kim; Sun Hee Kim; Seonyang Park; Su Yon Park; Joo Seop Chung; Jae Hoon Lee; Chan-Jeoung Park;
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Publication Detail:
Type:  Journal Article; Multicenter Study    
Journal Detail:
Title:  Leukemia & lymphoma     Volume:  49     ISSN:  1029-2403     ISO Abbreviation:  Leuk. Lymphoma     Publication Date:  2008 Apr 
Date Detail:
Created Date:  2008-04-09     Completed Date:  2008-08-04     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9007422     Medline TA:  Leuk Lymphoma     Country:  England    
Other Details:
Languages:  eng     Pagination:  700-9     Citation Subset:  IM    
Affiliation:
Department of Internal Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
Aged
B-Lymphocytes
Biological Markers / analysis
Female
Humans
Immunophenotyping
Korea
Leukemia, Biphenotypic, Acute / mortality,  pathology*
Male
Middle Aged
Myeloid Cells
Prognosis
Remission Induction
Retrospective Studies
Survival Analysis
T-Lymphocytes
Chemical
Reg. No./Substance:
0/Biological Markers

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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