| Prognostic implications of cytogenetic aberrations in diffuse large B-cell lymphomas. | |
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MedLine Citation:
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PMID: 10089896 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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A single institution series of 81 consecutive, cytogenetically analyzed, diffuse large B-cell lymphomas (DLBL), the majority of which treated with anthracycline-containing combination chemotherapy, were reviewed retrospectively to investigate whether the karyotypic pattern or certain abnormalities correlate with survival. Clonal chromosome changes were found in 79 of the 81 cases. The prognostic impact of the following aberrations, all suggested in previous studies to be associated with either shorter or longer survival, were tested: 1q21-23 breakpoints, +2/dup(2p), +3/dup(3p), +5, +6, 6q21-25 breakpoints, monosomy 7/der(7p)/i(7q), trisomy 7, 14q11-12 breakpoints, monosomy 17/der(17p)/i(17q), trisomy 18, > 4 marker chromosomes, > 4 breakpoints, and > or = 10 abnormalities. Univariate analysis showed that a breakpoint at 1q21-23 or trisomy 6 was associated with a shorter survival. However, when adjusted for age, stage, performance status and lactate dehydrogenase level, none of the cytogenetic aberrations had an independent prognostic value. Thus, the present investigation provides no support for any of the above-mentioned abnormalities being of prognostic importance in DLBL. |
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Authors:
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M Jerkeman; B Johansson; M Akerman; E Cavallin-Ståhl; U Kristoffersson; F Mitelman |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: European journal of haematology Volume: 62 ISSN: 0902-4441 ISO Abbreviation: Eur. J. Haematol. Publication Date: 1999 Mar |
Date Detail:
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Created Date: 1999-04-19 Completed Date: 1999-04-19 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8703985 Medline TA: Eur J Haematol Country: DENMARK |
Other Details:
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Languages: eng Pagination: 184-90 Citation Subset: IM |
Affiliation:
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Department of Oncology, University Hospital, Lund, Sweden. mats.jerkeman@onk.lu.se |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Aged, 80 and over B-Lymphocytes / pathology Chromosome Aberrations* Clone Cells / pathology Female Humans Karnofsky Performance Status L-Lactate Dehydrogenase / blood Life Tables Lymphoma, Large B-Cell, Diffuse / blood, genetics*, mortality Male Middle Aged Neoplastic Stem Cells / pathology Prognosis Proportional Hazards Models Retrospective Studies Survival Analysis |
| Chemical | |
Reg. No./Substance:
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EC 1.1.1.27/L-Lactate Dehydrogenase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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