Document Detail

Prognostic implications of bundle branch block in patients undergoing primary coronary angioplasty in the stent era.
MedLine Citation:
PMID:  20403479     Owner:  NLM     Status:  MEDLINE    
The presence of bundle branch block (BBB) in patients with ST-segment elevation myocardial infarction has been associated with a poor outcome. However, the implications of BBB in patients undergoing primary angioplasty in the stent era are poorly established. Furthermore, the prognostic implications of BBB type (right vs left and previous vs transient or persistent) remain unknown. We analyzed the data from 913 consecutive patients with ST-segment elevation myocardial infarction treated with primary angioplasty. All clinical, electrocardiographic, and angiographic data were prospectively collected. The median follow-up period was 19 months. The primary end point was the combined outcome of death and reinfarction. BBB was documented in 140 patients (15%). Right BBB (RBBB) was present in 119 patients (13%) and was previous in 27 (23%), persistent in 45 (38%), and transient in 47 (39%). Left BBB (LBBB) was present in 21 patients (2%) and was previous in 8 (38%), persistent in 9 (43%), and transient in 4 (19%). Patients with BBB were older, and more frequently had diabetes, anterior infarctions, a greater Killip class, a lower left ventricular ejection fraction, and greater mortality (all p <0.005) than patients without BBB. The short- and long-term primary outcome occurred more frequently in patients with persistent RBBB/LBBB than in those with previous or transient RBBB/LBBB. On multivariate analysis, persistent RBBB/LBBB emerged as an independent predictor of death and reinfarction. In conclusion, in patients undergoing primary angioplasty in the stent era, BBB is associated with poor short- and long-term prognosis. This risk appears to be particularly high among patients with persistent BBB.
David Vivas; Mar?a Jose P?rez-Vizcayno; Rosana Hern?ndez-Antol?n; Antonio Fern?ndez-Ortiz; Camino Ba?uelos; Javier Escaned; Pilar Jim?nez-Quevedo; Jose Alberto De Agust?n; Ivan N??ez-Gil; Juan Jose Gonz?lez-Ferrer; Carlos Macaya; Fernando Alfonso
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Publication Detail:
Type:  Comparative Study; Journal Article     Date:  2010-03-11
Journal Detail:
Title:  The American journal of cardiology     Volume:  105     ISSN:  1879-1913     ISO Abbreviation:  Am. J. Cardiol.     Publication Date:  2010 May 
Date Detail:
Created Date:  2010-04-20     Completed Date:  2010-06-15     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0207277     Medline TA:  Am J Cardiol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1276-83     Citation Subset:  AIM; IM    
Copyright Information:
Copyright 2010 Elsevier Inc. All rights reserved.
Cardiovascular Institute, San Carlos University Hospital, Madrid, Spain.
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MeSH Terms
Angioplasty, Transluminal, Percutaneous Coronary / methods*
Bundle-Branch Block / complications*,  diagnosis,  mortality
Follow-Up Studies
Hospital Mortality / trends
Length of Stay
Middle Aged
Myocardial Infarction / complications,  mortality,  therapy*
Retrospective Studies
Risk Factors
Spain / epidemiology
Survival Rate / trends
Time Factors

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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