Document Detail

Prognostic implications of aquaporin-4 antibody status in neuromyelitis optica patients.
MedLine Citation:
PMID:  20953960     Owner:  NLM     Status:  In-Data-Review    
Neuromyelitis optica (NMO) is an inflammatory/demyelinating disorder predominantly affecting the optic nerves and spinal cord. Recent findings showed an underlying humoral abnormality in NMO, characterized by a serum antibody against aquaporin-4 (Aqp-4-Ab). In this study, we evaluated the Aqp-4-Ab status among Turkish patients with NMO to determine the clinical and prognostic relevance. Serum samples from 35 consecutive patients with NMO followed at a single center and diagnosed according to the 2006 revised criteria, were evaluated for Aqp-4-Ab. All samples were obtained during a relapse prior to any immunosuppressive treatment. Aqp-4-Ab was positive in 21/35 (60%) patients. Among these cases, 11 had an EDSS of 6.0 or more, whereas only two patients in the seronegative group had such severe disability (p < 0.05). Overall, seropositive cases had a mean EDSS score of 5.1 ± 2.2 compared with 3.5 ± 1.7 in seronegative cases (p < 0.01). There were trends towards female predominance in seropositive cases and a monophasic course predominance in seronegative cases. Disease duration, age at onset, number of attacks and time to definite NMO did not differ between groups. Our findings in this single-center cohort suggest that the presence of Aqp-4-Ab might have a prognostic significance indicating a more severe disease course.
Gulsen Akman-Demir; Erdem Tüzün; Patrick Waters; Sema Içöz; Murat Kürtüncü; Sven Jarius; Zuhal Yapıcı; Melike Mutlu; Nilüfer Yeşilot; Angela Vincent; Mefkure Eraksoy
Publication Detail:
Type:  Journal Article     Date:  2010-10-17
Journal Detail:
Title:  Journal of neurology     Volume:  258     ISSN:  1432-1459     ISO Abbreviation:  J. Neurol.     Publication Date:  2011 Mar 
Date Detail:
Created Date:  2011-03-02     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0423161     Medline TA:  J Neurol     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  464-70     Citation Subset:  IM    
Department of Neurology, Istanbul Faculty of Medicine, Istanbul University, 34390, Çapa, Istanbul, Turkey,
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