| Prognostic implications of the NT-ProBNP level and left atrial size in non-ischemic dilated cardiomyopathy. | |
| | |
MedLine Citation:
|
PMID: 18728335 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
BACKGROUND: The ratio of peak early diastolic mitral inflow to annular velocity (E/E') and left atrial size could provide prognosis on congestive heart failure (CHF). N-terminal Pro B-type natriuretic peptide (NT-ProBNP) has also been useful for predicting adverse cardiac events. However, it is not clear how these parameters compare with conventional risk factors. Thus, we investigated whether E/E', left atrial dimension index (LADI) and NT-ProBNP would predict adverse events and add incremental value to conventional risk factors, even in non-ischemic advanced dilated cardiomyopathy (DCM). METHODS AND RESULTS: Both NT-ProBNP and echocardiography were evaluated in 105 patients. The cardiac events were defined as the composite of cardiac death and re-admission for CHF. At follow up, cardiac events occurred in 24 patients who had high NT-ProBNP and showed higher LADI and E/E'. In multivariate analysis, both NT-ProBNP and LADI, but not E/E', remained as independent predictors; patients with both increased LADI and NT-ProBNP had a 27-fold higher risk of cardiac events than those without any risk factors (p = 0.003). Moreover, LADI and NT-ProBNP showed a better incremental prognostic value over conventional risk factors (global chi-square increase from 7 to 17 to 49, p = 0.003, p < 0.001, respectively). CONCLUSIONS: Both NT-ProBNP and LADI might have the most predictable power, particularly in non-ischemic advanced DCM. |
| | |
Authors:
|
Hyungseop Kim; Yun-Kyeong Cho; Dong-Hwan Jun; Chang-Wook Nam; Seong-Wook Han; Seung-Ho Hur; Yoon-Nyun Kim; Kwon-Bae Kim |
Related Documents
:
|
15642535 - Bedside tests of b-type natriuretic peptide in the diagnosis of left ventricular diasto... 9609085 - Plasma n-terminal pro-brain natriuretic peptide and adrenomedullin: new neurohormonal p... 8651095 - Effects of aging on neuroendocrine activation in subjects and patients in the presence ... 12190955 - Differential regulation of atrial and brain natriuretic peptides and its implications f... 12431305 - Adrenergic nervous system influences on the induction of ventricular tachycardia. 6693615 - Chronic mitral regurgitation: predictive value of preoperative echocardiographic indexe... |
Publication Detail:
|
Type: Journal Article Date: 2008-08-27 |
Journal Detail:
|
Title: Circulation journal : official journal of the Japanese Circulation Society Volume: 72 ISSN: 1346-9843 ISO Abbreviation: Circ. J. Publication Date: 2008 Oct |
Date Detail:
|
Created Date: 2008-09-26 Completed Date: 2008-12-31 Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 101137683 Medline TA: Circ J Country: Japan |
Other Details:
|
Languages: eng Pagination: 1658-65 Citation Subset: IM |
Affiliation:
|
Division of Cardiology, Department of Internal Medicine, Keimyung University Dongsan Medical Center, Daegu, Korea. khyungseop@dsmc.or.kr |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Aged C-Reactive Protein / metabolism Cardiomyopathy, Dilated / blood*, pathology*, ultrasonography Diastole / physiology Electrocardiography Female Glomerular Filtration Rate Heart Atria / pathology*, ultrasonography Humans Male Middle Aged Mitral Valve / physiopathology Natriuretic Peptide, Brain / blood* Peptide Fragments / blood* Prognosis Systole / physiology |
| Chemical | |
Reg. No./Substance:
|
0/Peptide Fragments; 0/pro-brain natriuretic peptide (1-76); 114471-18-0/Natriuretic Peptide, Brain; 9007-41-4/C-Reactive Protein |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Clinical role of non-contrast magnetic resonance angiography for evaluation of renal artery stenosis...
Next Document: Comparison of biochemical data, blood pressure and physical activity between longevity and non-longe...