Document Detail


Prognostic implication of sequential bone marrow cultures in the myelodysplastic syndromes.
MedLine Citation:
PMID:  2607778     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Twenty-five patients with newly-diagnosed myelodysplastic syndromes were studied by the clonal culture method at least three times during the clinical course. Clinical outcomes of the patients were classified into: a stable disease (ten patients); subsequent leukemic transformation (eight patients) and nonleukemic death (seven patients). The growth of the marrow granulocyte-macrophage progenitors (CFU-GM) at the time of diagnosis was significantly related to the survival. In addition, sequential changes in the CFU-GM growth patterns correlated with the different clinical outcome of myelodysplastic syndromes patients.
Authors:
Y Yoshida; C Yoshida; K Tohyama; S Ohmori; M Ohmori; Y Ueda; Y Taniguchi; H Uchino
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Leukemia research     Volume:  13     ISSN:  0145-2126     ISO Abbreviation:  Leuk. Res.     Publication Date:  1989  
Date Detail:
Created Date:  1990-02-15     Completed Date:  1990-02-15     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  7706787     Medline TA:  Leuk Res     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  967-72     Citation Subset:  IM    
Affiliation:
Department of Medicine, Faculty of Medicine, Kyoto University, Japan.
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MeSH Terms
Descriptor/Qualifier:
Aged
Bone Marrow / pathology*
Cells, Cultured
Colony-Forming Units Assay
Follow-Up Studies
Hematopoiesis
Humans
Leukemia, Myeloid, Acute / pathology
Myelodysplastic Syndromes / diagnosis,  pathology*
Prognosis
Retrospective Studies

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