| Prognostic impact of peakVO2-changes in stable CHF on chronic beta-blocker treatment. | |
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MedLine Citation:
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PMID: 17222927 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Peak oxygen uptake (pVO2) is used for risk stratification in chronic heart failure (CHF), but little is known about the prognostic impact of pVO2-changes in patients on chronic beta-blocker (BBL) therapy. We therefore prospectively evaluated individual pVO2-changes at a 6-month interval in patients all receiving BBL. METHODS: 194 patients with stable CHF on stable medication were included (V1) and underwent clinical evaluation and exercise testing. Testing was repeated (V2) at 5.7+/-1.5 months after V1 and patients were followed >12 months after V2. Death or hospitalisation due to cardiac reasons was the predefined EP (EPP, end-point positive; n=62; EPN, end-point negative; n=113). RESULTS: Initial characteristics did not differ between EPP and EPN. Multivariate cox regression analysis revealed that change of pVO2 (EPP: -0.6+/-2.6 ml/kg min; EPN: +2.5+/-3.3 ml/kg min; p<0.001) was independent to pVO2, LVEF, NTproBNP and NYHA at V2 for prediction of the combined end-point during follow-up. An increase of pVO2 by 10% was identified as an adequate cut-off value for risk stratification and ROC-analysis showed the significant incremental prognostic value of the determination of pVO2 changes in combination with pVO2. CONCLUSIONS: Serial measurements of pVO2 yield additional information for risk stratification in clinically homogenous CHF patients receiving BBL. This is the first study demonstrating this fact within a narrow predefined interval with all patients on BBL. |
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Authors:
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L Frankenstein; M Nelles; M Hallerbach; D Dukic; A Fluegel; D Schellberg; H A Katus; A Remppis; C Zugck |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2007-01-12 |
Journal Detail:
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Title: International journal of cardiology Volume: 122 ISSN: 1874-1754 ISO Abbreviation: Int. J. Cardiol. Publication Date: 2007 Nov |
Date Detail:
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Created Date: 2007-10-16 Completed Date: 2007-11-07 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8200291 Medline TA: Int J Cardiol Country: Netherlands |
Other Details:
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Languages: eng Pagination: 125-30 Citation Subset: IM |
Affiliation:
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Department of Cardiology, Angiology, Pulmonology, University of Heidelberg, Im Neuenheimer Feld 410, D-69120 Heidelberg, Germany. Lutz.Frankenstein@med.uni-heidelberg.de |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Chi-Square Distribution Disease Progression Exercise Test Female Heart Failure / drug therapy*, physiopathology* Humans Male Middle Aged Multivariate Analysis Oxygen Consumption* Prognosis Prospective Studies ROC Curve Risk Assessment |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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