Document Detail


Prognostic impact of monosomal karyotype in young adult and elderly acute myeloid leukemia: the Southwest Oncology Group (SWOG) experience.
MedLine Citation:
PMID:  20562328     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Monosomal karyotype (MK), defined as 2 or more monosomies, or a single monosomy in the presence of structural abnormalities, has recently been reported as identifying a distinct subset of acute myeloid leukemia (AML) patients with an extremely poor prognosis. In an effort to confirm this observation, we analyzed the prognostic impact of MK in 1344 AML patients between the ages of 16 and 88 years treated on Southwest Oncology Group protocols. MK was found in 176 (13%) patients. The proportion of patients with MK increased with age, being present in 4% of patients age 30 or younger, but in 20% of those over age 60. Ninety-eight percent of MK cases were within the unfavorable cytogenetic risk category and comprised 40% of this group. The complete remission rate in patients with unfavorable cytogenetics without MK was 34% versus 18% with MK (P < .01). The 4-year overall survival of patients with unfavorable cytogenetics but without MK was 13% in contrast to a 4-year survival of only 3% with MK (P < .01). Thus, MK defines a sizeable subset of patients with unfavorable cytogenetics who have a particularly poor prognosis.
Authors:
Bruno C Medeiros; Megan Othus; Min Fang; Diane Roulston; Frederick R Appelbaum
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Publication Detail:
Type:  Journal Article     Date:  2010-06-18
Journal Detail:
Title:  Blood     Volume:  116     ISSN:  1528-0020     ISO Abbreviation:  Blood     Publication Date:  2010 Sep 
Date Detail:
Created Date:  2010-10-01     Completed Date:  2010-10-29     Revised Date:  2013-07-24    
Medline Journal Info:
Nlm Unique ID:  7603509     Medline TA:  Blood     Country:  United States    
Other Details:
Languages:  eng     Pagination:  2224-8     Citation Subset:  AIM; IM    
Affiliation:
Stanford University, Stanford Cancer Center, 875 Blake Wilbur Drive, Stanford, CA 94305-5821, USA. bruno.medeiros@stanford.edu
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MeSH Terms
Descriptor/Qualifier:
Adult
Age Factors
Aged
Chromosome Aberrations
Cytogenetic Analysis
Female
Humans
Kaplan-Meier Estimate
Karyotyping
Leukemia, Myeloid, Acute / classification,  genetics*,  mortality
Male
Middle Aged
Monosomy*
Prognosis
Grant Support
ID/Acronym/Agency:
U10 CA032102/CA/NCI NIH HHS
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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