Document Detail

Prognostic features of children with idiopathic dilated cardiomyopathy.
MedLine Citation:
PMID:  1835279     Owner:  NLM     Status:  MEDLINE    
The presenting features and long-term outcome of 39 children (median age 6.5 months, range 1 day to 16 years) with idiopathic dilated cardiomyopathy (IDC) were reviewed to help determine the appropriate management of these patients. Four outcome groups were identified: those who died, improved, had IDC resolved or received transplants. Presenting clinical features of age, sex, race, congestive heart failure, cardiomegaly, and degree of systolic ventricular dysfunction did not predict final outcome. Left ventricular hypertrophy on the electrocardiogram was seen significantly more often in children who improved than in those who died or in whom IDC resolved (p = 0.002). A rhythm disturbance was also seen more often in those who died than in those who survived (p = 0.025). Of 36 patients treated medically, 12 (33%) died, 15 (42%) improved and 9 (25%) resolved. Eighteen of 26 (69%) patients presenting at age less than or equal to 2 years survived, whereas 6 of 10 patients greater than 2 years survived. There were no differences based on age at presentation, in the time to death or time of follow-up. Three patients received orthotopic heart transplants, 1 of whom died from graft failure. Thus, no clinical feature including age at presentation consistently predicts ultimate outcome in children with IDC.
H B Wiles; P D McArthur; A B Taylor; P C Gillette; D A Fyfe; J P Matthews; L W Shelton
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The American journal of cardiology     Volume:  68     ISSN:  0002-9149     ISO Abbreviation:  Am. J. Cardiol.     Publication Date:  1991 Nov 
Date Detail:
Created Date:  1991-12-13     Completed Date:  1991-12-13     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0207277     Medline TA:  Am J Cardiol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1372-6     Citation Subset:  AIM; IM    
South Carolina Children's Heart Center, Medical University of South Carolina, Charleston 29425.
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MeSH Terms
Arrhythmias, Cardiac / epidemiology
Cardiomegaly / epidemiology
Cardiomyopathy, Dilated / diagnosis,  mortality*,  therapy
Heart Transplantation
Retrospective Studies
Treatment Outcome

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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