Document Detail

Prognostic factors in prenatally-detected posterior urethral valves: a multivariate analysis.
MedLine Citation:
PMID:  12598959     Owner:  NLM     Status:  MEDLINE    
To identify prognostic factors associated with chronic renal insufficiency in children with posterior urethral valves (PUV), 22 children with PUV were submitted to a systematic protocol and prospectively followed. Prognostic factors associated with fetal echography and clinical and laboratory findings were studied on admission. Median follow-up was 76 months. The analysis was conducted in two steps: in univariate analysis, variables associated with adverse outcome were identified by the Kaplan-Meier method. The variables that were significantly associated with adverse outcome were then included in a multivariate analysis using the Cox model. Eleven patients (50%) developed chronic renal failure (CRF) during follow-up. After adjustment by the multivariate model, four factors were identified as independent predictors of adverse outcome: oligohydramnios (relative risk [RR] = 10.6, 95% CI = 2.7 - 77, P = 0.02), ventilatory support (RR = 6, 95% CI = 2 - 24, P = 0.01), urea higher than 40 mg/dl (RR = 3.7, 95% CI = 0.92 - 15.0, P = 0.06), and bilateral vesicoureteral reflux (VUR) (RR = 6.1, 95% CI = 1.25 - 30, P = 0.02). On the other hand, the presence of unilateral VUR was a protective factor against the development of CRF or death during follow-up (RR = 0.92, 95% CI = 0.87 - 0.98, P = 0.05).
Eduardo A Oliveira; Eli A S Rabelo; Alamanda K Pereira; José S Diniz; Antônio C V Cabral; Henrique Vitor Leite; José M P Silva; Tiago A Fagundes
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2002-09-13
Journal Detail:
Title:  Pediatric surgery international     Volume:  18     ISSN:  0179-0358     ISO Abbreviation:  Pediatr. Surg. Int.     Publication Date:  2002 Dec 
Date Detail:
Created Date:  2003-02-24     Completed Date:  2003-05-01     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8609169     Medline TA:  Pediatr Surg Int     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  662-7     Citation Subset:  IM    
Pediatric Nephrourology Unit, Department of Pediatrics, Hospital das Clínicas, Federal University of Minas Gerais, Belo Horizonte, MG, Brazil.
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MeSH Terms
Child, Preschool
Follow-Up Studies
Hydronephrosis / embryology,  pathology*,  ultrasonography
Infant, Newborn
Multivariate Analysis
Proportional Hazards Models
Prospective Studies
Risk Factors
Ultrasonography, Prenatal
Urethra / abnormalities*

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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