| Prognostic factors in patients with primary transitional cell carcinoma of the upper urinary tract. | |
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MedLine Citation:
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PMID: 2398559 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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A total of 50 patients with primary transitional cell carcinoma of the upper urinary tract underwent deoxyribonucleic acid ploidy characterization by flow cytometric analysis of paraffin embedded specimens. The primary tumor was diploid in 29 patients (58%) and aneuploid in 21 (42%). Aneuploidy was identified more frequently in grade 3 than in grades 1 and 2 neoplasms (p = 0.001). Additionally, grade 3 neoplasms occurred more often with invasive (stages T2 to T3) compared to superficial (stages TA, TIS and T1) tumors (p = 0.002). However, deoxyribonucleic acid ploidy was not significantly associated with tumor stage. Among the 49 patients treated by a definitive operation the median survival free of disease and median over-all survival were 33.7 and more than 120 months, respectively. Variables examined included deoxyribonucleic acid ploidy, tumor grade, tumor stage, primary tumor site and type of operation. In the univariate analysis deoxyribonucleic acid ploidy was the only significant predictor of survival free of disease (p = 0.04). Aneuploid tumors had a median survival free of disease of 19 versus 59 months for diploid tumors. However, in the multivariate analysis of factors affecting survival free of disease, the type of operation performed was the only significant variable. Patients undergoing nephroureterectomy with en bloc bladder cuff excision had a favorable survival free of disease (p = 0.04). Tumor stage was the only significant factor associated with over-all survival in univariate and multivariate analyses (p = 0.02 and 0.005, respectively). Patients with superficial tumors had a median survival of more than 120 versus 72 months for patients with invasive tumors. The data suggest that deoxyribonucleic acid ploidy may be a useful parameter to identify risk groups and plan the management of patients with primary transitional cell carcinoma of the upper urinary tract. |
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Authors:
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R A Badalament; R V O'Toole; P Kenworthy; D C Young; S Keyhani-Rofagha; J Simon; J F Perez; J R Drago |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: The Journal of urology Volume: 144 ISSN: 0022-5347 ISO Abbreviation: J. Urol. Publication Date: 1990 Oct |
Date Detail:
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Created Date: 1990-10-18 Completed Date: 1990-10-18 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 0376374 Medline TA: J Urol Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 859-63 Citation Subset: AIM; IM |
Affiliation:
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Department of Surgery, Ohio State University, Columbus. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Carcinoma, Transitional Cell
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genetics,
mortality*,
surgery DNA, Neoplasm / genetics* Female Flow Cytometry Humans Kidney Neoplasms / genetics, mortality*, surgery Male Middle Aged Multivariate Analysis Ploidies Ureteral Neoplasms / genetics, mortality*, surgery |
| Grant Support | |
ID/Acronym/Agency:
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CA-1658-04/CA/NCI NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/DNA, Neoplasm |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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