Document Detail


Prognostic factors in patients undergoing surgery for severe necrotizing pancreatitis.
MedLine Citation:
PMID:  17687599     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Pancreatic necrosectomy remains an important treatment modality for the management of infected pancreatic necrosis but is associated with significant mortality. The aim of this study was to identify factors associated with mortality following pancreatic necrosectomy. Patients who underwent pancreatic necrosectomy from January 1995 to December 2004 were reviewed. The association between admission, preoperative and postoperative variables, and mortality was assessed using logistic regression analysis. A total of 1248 patients presented with acute pancreatitis, of whom 94 (7.5%) underwent pancreatic necrosectomy (51 men, 43 women). The preoperative median Acute Physiology, Age, and Chronic Health Evaluation (APACHE II) score was 9 (range 2-19). The median cumulative organ dysfunction score was 2 (0-9) preoperatively and 4 (1-11) postoperatively. In all, 23 patients (24.5%) died. Those who died were older than the survivors; the ages (median and range) were 69 years (40-80 years) versus 52 years (19-79 years) (p < 0.05). They also had higher admission APACHE II scores (median and range): 14 (12-19) versus 9 (2-22) (p < 0.001). There were significant associations between preoperative (p < 0.01) and postoperative (p < 0.01) Marshall scores and mortality following pancreatic necrosectomy. The presence of the systemic inflammatory response syndrome (SIRS) during the first 48 hours (p < 0.01) and the time between presentation and necrosectomy (p < 0.01) were independent predictors of survival. Pancreatic necrosectomy is associated with higher mortality in patients with increased APACHE II scores, early persistent SIRS, and unresolved multiorgan dysfunction. Necrosectomy is associated with poorer outcome when performed within 2 weeks of presentation.
Authors:
R Mofidi; A C Lee; K K Madhavan; O J Garden; R W Parks
Related Documents :
23796769 - Dermatology life quality index and side effects after topical photodynamic therapy of a...
24549209 - The effect of new method of suspension on quality of life, satisfaction, and suspension...
16500389 - Efficacy and safety of therapeutic ercp in patients 90 years of age and older.
23086079 - Changes in quality of life among prostate cancer patients after surgery.
23929509 - Outcome after modified putti-platt procedure for recurrent traumatic anterior shoulder ...
19201519 - Preclinical in vivo evaluation of an extracorporeal hifu device for ablation of pancrea...
20435259 - Bypass versus angioplasty in severe ischaemia of the leg (basil) trial: analysis of amp...
4000789 - Symptomatic gastroesophageal reflux following gastrostomy in neurologically impaired pa...
14587989 - Supramalleolar osteotomy for the treatment of distal tibial angular deformities and art...
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  World journal of surgery     Volume:  31     ISSN:  0364-2313     ISO Abbreviation:  World J Surg     Publication Date:  2007 Oct 
Date Detail:
Created Date:  2007-09-17     Completed Date:  2007-12-20     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7704052     Medline TA:  World J Surg     Country:  United States    
Other Details:
Languages:  eng     Pagination:  2002-7     Citation Subset:  IM    
Affiliation:
Department of Clinical and Surgical Sciences, University of Edinburgh, Royal Infirmary of Edinburgh, Old Dalkeith Road, Edinburgh, UK.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
APACHE
Adult
Aged
C-Reactive Protein / analysis
Female
Humans
Logistic Models
Male
Middle Aged
Pancreatectomy
Pancreatitis, Acute Necrotizing / etiology,  mortality*,  radiography
Prognosis
Reoperation
Surgical Procedures, Minimally Invasive
Tomography, X-Ray Computed
Chemical
Reg. No./Substance:
9007-41-4/C-Reactive Protein

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Extent of routine central lymph node dissection with small papillary thyroid carcinoma.
Next Document:  Thoracoscopic sympathectomy for primary palmar hyperhidrosis: resection versus transection -- a pros...