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Prognostic factors in methylprednisolone pulse therapy for alopecia areata.
MedLine Citation:
PMID:  21592197     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Many treatments induce remission in patients with alopecia areata. Systemic steroids, for example, are effective in the treatment of severe alopecia areata but have many side-effects. To avoid these side-effects, high-dose bolus infusions of methylprednisolone have been used to treat severe alopecia areata. The purpose of this study was to evaluate the prognostic factors associated with pulse therapy and to establish proper indications for methylprednisolone pulse therapy. Seventy patients with severe alopecia areata were treated i.v. with methylprednisolone on 3 consecutive days. All of the patients had rapid and extensive hair loss with the bald area exceeding 50% of the scalp. Seventy percent of the patients showed terminal hair growth and 41.4% showed complete responses with acceptable cosmetic outcomes. The prognostic factors that influenced successful outcome were the disease duration before treatment and the type of alopecia areata. Based on these two factors, a good response was obtained for all types of alopecia areata with a duration of 3 months or less before treatment and for the plurifocal type of alopecia areata with a duration of 4-6 months. Methylprednisolone pulse therapy is indicated for those alopecia areata patients who fall within our good response group.
Authors:
Myung Im; Sang Sin Lee; Young Lee; Chang Deok Kim; Young Joon Seo; Jeung Hoon Lee; Jang Kyu Park
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-5-19
Journal Detail:
Title:  The Journal of dermatology     Volume:  -     ISSN:  1346-8138     ISO Abbreviation:  -     Publication Date:  2011 May 
Date Detail:
Created Date:  2011-5-19     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7600545     Medline TA:  J Dermatol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
© 2011 Japanese Dermatological Association.
Affiliation:
Department of Dermatology, Chungnam National University Hospital, Daejeon, Korea.
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